Human immunodeficiency virus drug therapy and virus load

被引：150

作者：

Bonhoeffer, S ^{[1
]}

Coffin, JM ^{[1
]}

Nowak, MA ^{[1
]}

机构：

[1] TUFTS UNIV, DEPT MOL BIOL & MICROBIOL, BOSTON, MA 02111 USA

来源：

JOURNAL OF VIROLOGY | 1997年 / 71卷 / 04期

基金：

英国惠康基金;

关键词：

D O I：

10.1128/JVI.71.4.3275-3278.1997

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Analysis of the short-term dynamics of human immunodeficiencg virus (HIV) type 1 infection in response to drug therapy has elucidated crucial kinetic properties of viral dynamics in vivo (D. D. Ho et al., Nature 373:123-126, 1995; A. S. Perelson et al., Science 271:1582-1586, 1996; X. Wei et al., Nature 373:117-122, 1995). Here we investigated long-term changes in virus Load in patients treated with a combination of lamivudine and zidovudine to identify principal factors responsible for the observed 10- to 100-fold sustained suppression of virus load in vivo. Interestingly, most standard accounts of virus dynamics cannot explain a large sustained reduction without shifting the virus very close to extinction. The effect can be explained by taking into consideration either (i) the immune response against HIV, (ii) the killing of uninfected CD4 cells, or (iii) the differential efficacies of the drugs in different cell populations.

引用

页码：3275 / 3278

页数：4

共 23 条

[1]

ANDERSON R M, 1991

[2]

Anderson R. M., 1993, P75, DOI 10.1002/9781444313963.ch4

[3] POPULATION BIOLOGY OF INFECTIOUS-DISEASES .1. [J].

ANDERSON, RM ;

MAY, RM .

NATURE, 1979, 280 (5721) :361-367

[4] HIV POPULATION-DYNAMICS IN-VIVO - IMPLICATIONS FOR GENETIC-VARIATION, PATHOGENESIS, AND THERAPY [J].

COFFIN, JM .

SCIENCE, 1995, 267 (5197) :483-489

[5] TREATMENT WITH LAMIVUDINE, ZIDOVUDINE, OR BOTH IN HIV-POSITIVE PATIENTS WITH 200 TO 500 CD4+ CELLS PER CUBIC MILLIMETER [J].

ERON, JJ ;

BENOIT, SL ;

JEMSEK, J ;

MACARTHUR, RD ;

SANTANA, J ;

QUINN, JB ;

KURITZKES, DR ;

FALLON, MA ;

RUBIN, M .

NEW ENGLAND JOURNAL OF MEDICINE, 1995, 333 (25) :1662-1669

[6] Viral dynamics in vivo: Limitations on estimates of intracellular delay and virus decay [J].

Herz, AVM ;

Bonhoeffer, S ;

Anderson, RM ;

May, RM ;

Nowak, MA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (14) :7247-7251

[7] RAPID TURNOVER OF PLASMA VIRIONS AND CD4 LYMPHOCYTES IN HIV-1 INFECTION [J].

HO, DD ;

NEUMANN, AU ;

PERELSON, AS ;

CHEN, W ;

LEONARD, JM ;

MARKOWITZ, M .

NATURE, 1995, 373 (6510) :123-126

[8] Contributions to the mathematical theory of epidemics III - Further studies of this problem of endemicity [J].

Kermack, WO ;

McKendrick, AG .

PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES A-CONTAINING PAPERS OF A MATHEMATICAL AND PHYSICAL CHARACTER, 1933, 141 (843) :94-122

[9] POTENTIAL MECHANISM FOR SUSTAINED ANTIRETROVIRAL EFFICACY OF AZT-3TC COMBINATION THERAPY [J].

LARDER, BA ;

KEMP, SD ;

HARRIGAN, PR .

SCIENCE, 1995, 269 (5224) :696-699

[10]

Levy JA, 1994, HIV and the pathogenesis of AIDS

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