Strategies for expressing human antibody repertoires in transgenic mice

被引：68

作者：

Bruggemann, M ^{[1
]}

Neuberger, MS ^{[1
]}

机构：

[1] MRC,MOL BIOL LAB,CAMBRIDGE CB2 2QH,ENGLAND

来源：

IMMUNOLOGY TODAY | 1996年 / 17卷 / 08期

关键词：

D O I：

10.1016/0167-5699(96)10025-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Repertoires of human antibodies can be created in transgenic mice carrying human immunoglobulin-gene loci in germline configuration. These 'transloci', introduced either as miniloci or as almost locus-sized regions, undergo rearrangement and hypermutation in mouse lymphoid tissue. Here, Marianne Bruggemann and Michael Neuberger review the use of such mice for raising antigen-specific human monoclonal antibodies, as well as their exploitation for studying regulatory aspects of antibody repertoire formation.

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页码：391 / 397

页数：7

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