Mapping of human WHN gene in a 17q11.2 YAC contig and identification of an intragenic STR

被引：2

作者：

Corrado, L ^{[1
]}

Colapietro, P ^{[1
]}

Larizza, I ^{[1
]}

Riva, P ^{[1
]}

机构：

[1] Univ Milan, Fac Med, Dept Biol & Genet, I-20133 Milan, Italy

来源：

MOLECULAR AND CELLULAR PROBES | 1999年 / 13卷 / 03期

关键词：

human WHN gene; STR; retinal; 4; gene; sodium dicarboxylate cotransporter gene; YAC contig;

D O I：

10.1006/mcpr.1999.0237

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The recently isolated human WHN gene has been previously assigned to chromosome 17q11-12 using radiation hybrids. In this study, we constructed a YAC contig covering 17q11.2 between crystallinBA1 and neurofibromatosis 1 genes. By ordering known and novel markers, we determined the position of the WHN gene, and of the closely linked retinal 4 and sodium/dicarboxylate cotransporter genes. We also identified a new mononucleotide polymorphism contained within the untranslated exon 1 of the WHN gene, which may be useful for linkage and LOH studies. (C) 1999 Academic Press.

引用

页码：199 / 202

页数：4

共 12 条

[1]

CHUMAKOV IM, 1995, NATURE, V377, P175

[2]

FAIN PR, 1989, CYTOGENET CELL GENET, V51, P996

[3] IRE-BUBBLE PCR - A RAPID METHOD FOR EFFICIENT AND REPRESENTATIVE AMPLIFICATION OF HUMAN GENOMIC DNA-SEQUENCES FROM COMPLEX SOURCES [J].

MUNROE, DJ ;

HAAS, M ;

BRIC, E ;

WHITTON, T ;

ABURATANI, H ;

HUNTER, K ;

WARD, D ;

HOUSMAN, DE .

GENOMICS, 1994, 19 (03) :506-514

[4] Two genetically separable steps in the differentiation of thymic epithelium [J].

Nehls, M ;

Kyewski, B ;

Messerle, M ;

Waldschutz, R ;

Schuddekopf, K ;

Smith, AJH ;

Boehm, T .

SCIENCE, 1996, 272 (5263) :886-889

[5] NEW MEMBER OF THE WINGED-HELIX PROTEIN FAMILY DISRUPTED IN MOUSE AND RAT NUDE MUTATIONS [J].

NEHLS, M ;

PFEIFER, D ;

SCHORPP, M ;

HEDRICH, H ;

BOEHM, T .

NATURE, 1994, 372 (6501) :103-107

[6] ALU POLYMERASE CHAIN-REACTION - A METHOD FOR RAPID ISOLATION OF HUMAN-SPECIFIC SEQUENCES FROM COMPLEX DNA SOURCES [J].

NELSON, DL ;

LEDBETTER, SA ;

CORBO, L ;

VICTORIA, MF ;

RAMIREZSOLIS, R ;

WEBSTER, TD ;

LEDBETTER, DH ;

CASKEY, CT .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (17) :6686-6690

[7] ALU-PRIMED POLYMERASE CHAIN-REACTION FOR REGIONAL ASSIGNMENT OF 110 YEAST ARTIFICIAL CHROMOSOME CLONES FROM THE HUMAN X-CHROMOSOME - IDENTIFICATION OF CLONES ASSOCIATED WITH A DISEASE LOCUS [J].

NELSON, DL ;

BALLABIO, A ;

VICTORIA, MF ;

PIERETTI, M ;

BIES, RD ;

GIBBS, RA ;

MALEY, JA ;

CHINAULT, AC ;

WEBSTER, TD ;

CASKEY, CT .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (14) :6157-6161

[8] Characterization of a cytogenetic 17q11.2 deletion in an NF1 patient with a contiguous gene syndrome [J].

Riva, P ;

Castorina, P ;

Manoukian, S ;

Dalpra, L ;

Doneda, L ;

Marini, G ;

denDunnen, J ;

Larizza, L .

HUMAN GENETICS, 1996, 98 (06) :646-650

[9] The nude gene encodes a sequence-specific DNA binding protein with homologs in organisms that lack an anticipatory immune system [J].

Schlake, T ;

Schorpp, M ;

Nehls, M ;

Boehm, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (08) :3842-3847

[10] Characterization of mouse and human nude genes [J].

Schorpp, M ;

Hofmann, M ;

Dear, TN ;

Boehm, T .

IMMUNOGENETICS, 1997, 46 (06) :509-515

← 1 2 →