It Is Possible to Classify Non-erosive Reflux Disease (NERD) Patients into Endoscopically Normal Groups and Minimal Change Groups by Subjective Symptoms and Responsiveness to Rabeprazole-A Report from a Study with Japanese Patients

被引：23

作者：

Kusano, Motoyasu ^{[1
]}

Shirai, Naohito ^{[2
]}

Yamaguchi, Kanako ^{[3
]}

Hongo, Michio ^{[4
,5
]}

Chiba, Tsutomu ^{[6
]}

Kinoshita, Yoshikazu ^{[7
]}

机构：

[1] Gunma Univ Hosp, Dept Endoscopy & Endoscop Surg, Gunma 3718511, Japan

[2] Enshu Hosp, Dept Gastroenterol, Hamamatsu, Shizuoka, Japan

[3] Saga Med Sch, Dept Internal Med, Saga, Japan

[4] Tohoku Univ Hosp, Dept Comprehens Med, Sendai, Miyagi, Japan

[5] Tohoku Univ Hosp, Dept Psychosomat Med, Sendai, Miyagi, Japan

[6] Kyoto Univ, Dept Gastroenterol & Hepatol, Grad Sch Med, Kyoto, Japan

[7] Shimane Univ, Dept Gastroenterol & Hepatol, Izumo, Shimane, Japan

来源：

DIGESTIVE DISEASES AND SCIENCES | 2008年 / 53卷 / 12期

关键词：

NERD; Symptom; Rabeprazole; Minimal change; Questionnaire;

D O I：

10.1007/s10620-008-0290-2

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The hypothesis that non-erosive reflux disease (NERD) patients comprise various subgroups is gaining popularity. This study was conducted to investigate the possibility of categorizing NERD patients according to symptom types and response to acid-suppressive drug rabeprazole (RPZ) 10 mg/day. NERD patients were classified as grade N (endoscopically normal), M (minimal change), or erosive GERD, and answered a 51-item, yes-or-no questionnaire pre and post-treatment. Compared to erosive GERD, clear differences existed in pretreatment prevalence of symptoms and responsiveness to RPZ in grades N and M; the results suggested stomachaches (especially at night) were significant symptoms in grade N and dysmotility-like symptoms like bloated stomach were significant in grade M while gastroesophageal reflux symptoms were significant in erosive GERD. Clinical significance of classifying NERD was indicated from different symptoms and responsiveness to PPI.

引用

页码：3082 / 3094

页数：13

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