Melatonin: circadian rhythm regulator, chronobiotic, antioxidant and beyond

被引：41

作者：

Berra, Bruno ^{[1
]}

Rizzo, Angela Maria ^{[1
]}

机构：

[1] Univ Milan, Fac Pharm, Inst Gen Physiol & Biochem, I-20134 Milan, Italy

来源：

CLINICS IN DERMATOLOGY | 2009年 / 27卷 / 02期

关键词：

HUMAN PINEAL-GLAND; ALZHEIMERS-DISEASE; CEREBROSPINAL-FLUID; OXIDATIVE STRESS; SUPRACHIASMATIC NUCLEUS; EXOGENOUS MELATONIN; RETINAL PATHOLOGY; SERUM MELATONIN; GENE-EXPRESSION; LIGHT EXPOSURE;

D O I：

10.1016/j.clindermatol.2008.04.003

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

For many years, melatonin has been known to interact with circadian rhythms. New evidence indicates that melatonin acts as a free radical scavenger and antioxidant. Moreover, melatonin prevents apoptosis in different types of cells, because it induces mRNA levels of several antioxidant enzymes. It is evident that melatonin is involved in the cellular bioenergetic system as a mechanism that counteracts the progression of Alzheimer's disease. (c) 2009 Elsevier Inc. All rights reserved.

引用

页码：202 / 209

页数：8

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