Complementarity of combinatorial chemistry and structure-based ligand design: Application to the discovery of novel inhibitors of matrix metalloproteinases

被引:86
作者
Rockwell, A [1 ]
Melden, M [1 ]
Copeland, RA [1 ]
Hardman, K [1 ]
Decicco, CP [1 ]
DeGrado, WF [1 ]
机构
[1] DUPONT MERCK PHARMACEUT CO, CHEM & PHYS SCI, EXPT STN, WILMINGTON, DE 19880 USA
关键词
D O I
10.1021/ja960897t
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
[No abstract available]
引用
收藏
页码:10337 / 10338
页数:2
相关论文
共 18 条
[1]   MATRIX METALLOPROTEINASE INHIBITORS CONTAINING A (CARBOXYALKYL)AMINO ZINC LIGAND - MODIFICATION OF THE P1 AND P2' RESIDUES [J].
BROWN, FK ;
BROWN, PJ ;
BICKETT, DM ;
CHAMBERS, CL ;
DAVIES, HG ;
DEATON, DN ;
DREWRY, D ;
FOLEY, M ;
MCELROY, AB ;
GREGSON, M ;
MCGEEHAN, GM ;
MYERS, PL ;
NORTON, D ;
SALOVICH, JM ;
SCHOENEN, FJ ;
WARD, P .
JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (05) :674-688
[2]   INHIBITION OF MATRIX METALLOPROTEINASES BY N-CARBOXYALKYL PEPTIDES [J].
CHAPMAN, KT ;
KOPKA, IE ;
DURETTE, PL ;
ESSER, CK ;
LANZA, TJ ;
IZQUIERDOMARTIN, M ;
NIEDZWIECKI, L ;
CHANG, B ;
HARRISON, RK ;
KUO, DW ;
LIN, TY ;
STEIN, RL ;
HAGMANN, WK .
JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (26) :4293-4301
[3]   ESTIMATING K-I VALUES FOR TIGHT-BINDING INHIBITORS FROM DOSE-RESPONSE PLOTS [J].
COPELAND, RA ;
LOMBARDO, D ;
GIANNARAS, J ;
DECICCO, CP .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1995, 5 (17) :1947-1952
[4]   INHIBITION OF MATRIX METALLOPROTEINASES BY N-CARBOXYALKYL PEPTIDES CONTAINING EXTENDED ALKYL RESIDUES AT P-1 [J].
ESSER, CK ;
KOPKA, IE ;
DURETTE, PL ;
HARRISON, RK ;
NIEDZWIECKI, LM ;
IZQUIERDOMARTIN, M ;
STEIN, RL ;
HAGMANN, WK .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1995, 5 (06) :539-542
[5]  
FOSANG AJ, 1992, J BIOL CHEM, V267, P19470
[6]   APPLICATIONS OF COMBINATORIAL TECHNOLOGIES TO DRUG DISCOVERY .1. BACKGROUND AND PEPTIDE COMBINATORIAL LIBRARIES [J].
GALLOP, MA ;
BARRETT, RW ;
DOWER, WJ ;
FODOR, SPA ;
GORDON, EM .
JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (09) :1233-1251
[7]   APPLICATIONS OF COMBINATORIAL TECHNOLOGIES TO DRUG DISCOVERY .2. COMBINATORIAL ORGANIC-SYNTHESIS, LIBRARY SCREENING STRATEGIES, AND FUTURE-DIRECTIONS [J].
GORDON, EM ;
BARRETT, RW ;
DOWER, WJ ;
FODOR, SPA ;
GALLOP, MA .
JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (10) :1385-1401
[8]  
GOWAVARAM MR, 1995, J MED CHEM, V38, P2570
[9]  
GREENWALD RA, 1994, INHIBITION MATRIX ME, V732
[10]  
HARDMAN KD, UNPUB