INHIBITION OF MATRIX METALLOPROTEINASES BY N-CARBOXYALKYL PEPTIDES CONTAINING EXTENDED ALKYL RESIDUES AT P-1

被引：15

作者：

ESSER, CK ^{[1
]}

KOPKA, IE ^{[1
]}

DURETTE, PL ^{[1
]}

HARRISON, RK ^{[1
]}

NIEDZWIECKI, LM ^{[1
]}

IZQUIERDOMARTIN, M ^{[1
]}

STEIN, RL ^{[1
]}

HAGMANN, WK ^{[1
]}

机构：

[1] MERCK & CO INC,RES LABS,DEPT ENZYMOL,RAHWAY,NJ 07065

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 06期

关键词：

D O I：

10.1016/0960-894X(95)00079-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of N-carboxyalkyl peptides were prepared to test their inhibitory activity against human stromelysin (MMP-3), collagenase (MMP-1), and gelatinase A (MMP-2). Linear alkyl and omega-aminoalkyl residues were employed as replacements for a phenethyl group yielding inhibitors with in vitro activities comparable to their corresponding aromatic analogs.

引用

页码：539 / 542

页数：4

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