Chemoselective amide ligations by decarboxylative condensations of N-alkylhydroxylamines and α-ketoacids

被引：355

作者：

Bode, JW ^{[1
]}

Fox, RM ^{[1
]}

Baucom, KD ^{[1
]}

机构：

[1] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 08期

关键词：

amides; chemoselectivity; ketoacids; ligation reactions; peptides;

D O I：

10.1002/anie.200503991

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Additive-free: The chemoselective amide-bond-forming ligation between N-alkylhydroxylamines and α-ketoacids requires no reagents and the only by-products are water and carbon dioxide. This process proceeds on unprotected peptide substrates without epimerization, and as such, this process has the potential to serve as a novel chemoselective ligation for the synthesis of peptides and complex materials. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1248 / 1252

页数：5

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