Hemiaminal generated by hydration of ketone-based nitrone as an N,O-centered nucleophile in organic synthesis

被引:29
作者
Ishikawa, T [1 ]
Nagai, K [1 ]
Senzaki, M [1 ]
Tatsukawa, A [1 ]
Saito, S [1 ]
机构
[1] Okayama Univ, Fac Engn, Dept Biosci & Biotechnol, Okayama 700, Japan
关键词
D O I
10.1016/S0040-4020(98)00008-8
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Isoxazolidines that are useful precursors for beta-amino acids have been prepared relying on intermolecular amino Michael addition-intramolecular S(N)2 displacement employing hydroxylamine or hydrate of ketone-based nitrone as an N- and O-centered binucleophile. (C) 1998 Elsevier Science Ltd. All rights reserved.
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页码:2433 / 2448
页数:16
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