Biomarkers: Coming of age for environmental health and risk assessment

被引:94
作者
Decaprio, AP
机构
[1] ChemRisk Division, McLaren/Hart, Inc., Albany, NY 12203
关键词
D O I
10.1021/es960920a
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Biological markers, or biomarkers, reflect molecular and cellular alterations that occur along the temporal and mechanistic pathways connecting exposure to toxic chemicals or physical agents and the presence or risk of clinical disease. Biomarkers include a vast array of measurements that reflect exposure, effect, and/or susceptibility. The development and validation of potential biomarkers is a long-term endeavor that proceeds from basic research to pilot human studies to full-scale epidemiological investigations. The past decade has seen extensive research investigation of biomarkers and the beginnings of their practical application for risk assessment and environmental health management. These potential applications include improved exposure characterization and dose-response assessment, measurement of interindividual variability, and evaluation of causation in toxic tort and environmental litigation. This paper reviews the biomarker paradigm as applied to xenobiotic exposure in humans, discusses progress toward applying biomarker technology in environmental epidemiology, and summarizes recent biomarker data for three important environmental and occupational agents, benzo[a]pyrene, 1,3-butadiene, and acrylamide.
引用
收藏
页码:1837 / 1848
页数:12
相关论文
共 209 条
[61]   MOLECULAR DOSIMETRY OF URINARY AFLATOXIN-N7-GUANINE AND SERUM AFLATOXIN ALBUMIN ADDUCTS PREDICTS CHEMOPROTECTION BY 1,2-DITHIOLE-3-THIONE IN RATS [J].
GROOPMAN, JD ;
DEMATOS, P ;
EGNER, PA ;
LOVEHUNT, A ;
KENSLER, TW .
CARCINOGENESIS, 1992, 13 (01) :101-106
[62]   Molecular epidemiology and human risk monitoring [J].
Groopman, JD ;
Kensler, TW ;
Links, JM .
TOXICOLOGY LETTERS, 1995, 82-3 :763-769
[63]   DETECTION OF BENZO[A]PYRENE DIOL EPOXIDE DNA ADDUCTS IN PERIPHERAL-BLOOD LYMPHOCYTES AND ANTIBODIES TO THE ADDUCTS IN SERUM FROM COKE-OVEN WORKERS [J].
HARRIS, CC ;
VAHAKANGAS, K ;
NEWMAN, MJ ;
TRIVERS, GE ;
SHAMSUDDIN, A ;
SINOPOLI, N ;
MANN, DL ;
WRIGHT, WE .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (19) :6672-6676
[65]   MEASUREMENT ISSUES IN ENVIRONMENTAL EPIDEMIOLOGY [J].
HATCH, M ;
THOMAS, D .
ENVIRONMENTAL HEALTH PERSPECTIVES, 1993, 101 :49-57
[66]   AMBIENT, BIOLOGICAL, AND BIOLOGICAL EFFECT MONITORING OF EXPOSURE TO POLYCYCLIC AROMATIC-HYDROCARBONS (PAHS) [J].
HATJIAN, BA ;
EDWARDS, JW ;
HARRISON, J ;
WILLIAMS, FM ;
BLAIN, PG .
TOXICOLOGY LETTERS, 1995, 77 (1-3) :271-279
[67]  
Hattan D G, 1986, Regul Toxicol Pharmacol, V6, P181
[70]  
HATTIS D, 1988, STAT SCI, V3, P358