Obesity and type 2 diabetes mellitus: A treatment challenge

被引:4
作者
Gumbiner, B [1 ]
Battiwalla, M [1 ]
机构
[1] Merck & Co Inc, Merck Res Labs, Clin Res Endocrinol & Metab, Rahway, NJ 07065 USA
关键词
D O I
10.1097/00019616-200201000-00007
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
This article discusses the pathophysiologic relationship between type 2 diabetes mellitus and obesity and the effect of obesity on the complications of that disease. It is concluded that obesity plays an important role in type 2 diabetes and that modulating body weight can be an important therapeutic modality in treating this illness.
引用
收藏
页码:23 / 28
页数:6
相关论文
共 61 条
[51]   Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34) [J].
Turner, RC ;
Holman, RR ;
Stratton, IM ;
Cull, CA ;
Matthews, DR ;
Manley, SE ;
Frighi, V ;
Wright, D ;
Neil, A ;
Kohner, E ;
McElroy, H ;
Fox, C ;
Hadden, D .
LANCET, 1998, 352 (9131) :854-865
[52]   Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33) [J].
Turner, RC ;
Holman, RR ;
Cull, CA ;
Stratton, IM ;
Matthews, DR ;
Frighi, V ;
Manley, SE ;
Neil, A ;
McElroy, K ;
Wright, D ;
Kohner, E ;
Fox, C ;
Hadden, D ;
Mehta, Z ;
Smith, A ;
Nugent, Z ;
Peto, R ;
Adlel, AI ;
Mann, JI ;
Bassett, PA ;
Oakes, SF ;
Dornan, TL ;
Aldington, S ;
Lipinski, H ;
Collum, R ;
Harrison, K ;
MacIntyre, C ;
Skinner, S ;
Mortemore, A ;
Nelson, D ;
Cockley, S ;
Levien, S ;
Bodsworth, L ;
Willox, R ;
Biggs, T ;
Dove, S ;
Beattie, E ;
Gradwell, M ;
Staples, S ;
Lam, R ;
Taylor, F ;
Leung, L ;
Carter, RD ;
Brownlee, SM ;
Fisher, KE ;
Islam, K ;
Jelfs, R ;
Williams, PA ;
Williams, FA ;
Sutton, PJ .
LANCET, 1998, 352 (9131) :837-853
[53]   DIMINISHED B-CELL SECRETORY CAPACITY IN PATIENTS WITH NONINSULIN-DEPENDENT DIABETES-MELLITUS [J].
WARD, WK ;
BOLGIANO, DC ;
MCKNIGHT, B ;
HALTER, JB ;
PORTE, D .
JOURNAL OF CLINICAL INVESTIGATION, 1984, 74 (04) :1318-1328
[54]   OBESITY, LIPIDS, CARDIOVASCULAR RISK, AND ANDROGEN EXCESS [J].
WILD, RA .
AMERICAN JOURNAL OF MEDICINE, 1995, 98 :S27-S32
[55]   LONG-TERM EFFECTS OF MODEST WEIGHT-LOSS IN TYPE-II DIABETIC-PATIENTS [J].
WING, RR ;
KOESKE, R ;
EPSTEIN, LH ;
NOWALK, MP ;
GOODING, W ;
BECKER, D .
ARCHIVES OF INTERNAL MEDICINE, 1987, 147 (10) :1749-1753
[56]   Small weight loss on long-term acarbose therapy with no change in dietary pattern or nutrient intake of individuals with non-insulin-dependent diabetes [J].
Wolever, TMS ;
Chiasson, JL ;
Josse, RG ;
Hunt, JA ;
Palmason, C ;
Rodger, NW ;
Ross, SA ;
Ryan, EA ;
Tan, MH .
INTERNATIONAL JOURNAL OF OBESITY, 1997, 21 (09) :756-763
[57]   United kingdom prospective diabetes study 24: A 6-year, randomized, controlled trial comparing sulfonylurea, insulin, and metformin therapy in patients with newly diagnosed type 2 diabetes that could not be controlled with diet therapy [J].
Wright, A ;
Cull, C ;
Holman, R ;
Turner, R ;
Murchison, L ;
Wright, AD ;
Oakley, N ;
Kohner, E ;
Hayes, R ;
Scarpello, J ;
Hadden, D ;
Spathis, AG ;
Yudkin, J ;
Greenwood, R ;
Borthwick, L ;
Day, J ;
Newton, R ;
Fox, C ;
Paisey, R ;
Roland, J ;
Humphriss, D ;
Peacock, I ;
Boulton, A ;
Dornan, T ;
Burden, F ;
Tooke, J .
ANNALS OF INTERNAL MEDICINE, 1998, 128 (03) :165-175
[58]   Insulin resistance and body fat distribution - Contribution of visceral fat accumulation to the development of insulin resistance and atherosclerosis [J].
Yamashita, S ;
Nakamura, T ;
Shimomura, I ;
Nishida, M ;
Yoshida, S ;
Kotani, K ;
KamedaTakemuara, K ;
Tokunaga, K ;
Matsuzawa, Y .
DIABETES CARE, 1996, 19 (03) :287-291
[59]  
Yanovski SZ, 1999, AM J CLIN NUTR, V69, P366
[60]   Effect of obesity on the response to insulin therapy in noninsulin-dependent diabetes mellitus [J].
Yki-Järvinen, H ;
Ryysy, L ;
Kauppila, M ;
Kujansuu, E ;
Lahti, J ;
Marjanen, T ;
Niskanen, L ;
Rajala, S ;
Salo, S ;
Seppälä, P ;
Tulokas, T ;
Viikari, J ;
Taskinen, MR .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1997, 82 (12) :4037-4043