cervical cancer;
human papillomavirus;
plasma DNA;
postradiotherapy;
recurrence;
D O I:
10.1111/j.1525-1438.2006.00550.x
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
To understand the role of human papillomavirus (HPV) in recurrence of uterine cervical cancer (CA-CX) after radiotherapy, we have analyzed the HPV prevalence in the exfoliated cells of 56 patients and their corresponding plasma. HPV DNA was detected in exfoliated cells of 78% (44/56) patients (HPV-16, 68%; HPV-18, 14%; HPV-X [other than 16, 18], 11%; and mixed infection of HPV-16 and HPV-18 in three cases). HPV DNA in plasma was present in only 25% (11/44) of the HPV-positive exfoliated cells (positive predictive value, 100%; negative predictive value, 27%) with concordance in HPV types. The recurrence of the disease was significantly associated with the presence of HPV in the exfoliated cell (P = 0.01) and plasma (P = 0.007) as well as high viral load in the exfoliated cell (P = 0.0002). Kaplan-Meier disease-free estimates have also shown the significant association between HPV prevalence in plasma and recurrence of the disease (P = 0.045). Thus, it indicates that in postradiotherapy CA-CX patients, the high viral load in the exfoliated cell as well as HPV presence in the plasma samples could be used in early detection of the patients at increased risk for disease recurrence and progression.
机构:
Univ Hong Kong, Dept Obstet & Gynecol, Pokfulam, Hong Kong, Peoples R ChinaUniv Hong Kong, Dept Obstet & Gynecol, Pokfulam, Hong Kong, Peoples R China
Yang, HJ
;
Liu, VWS
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机构:
Univ Hong Kong, Dept Obstet & Gynecol, Pokfulam, Hong Kong, Peoples R ChinaUniv Hong Kong, Dept Obstet & Gynecol, Pokfulam, Hong Kong, Peoples R China
Liu, VWS
;
Tsang, PCK
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机构:
Univ Hong Kong, Dept Obstet & Gynecol, Pokfulam, Hong Kong, Peoples R ChinaUniv Hong Kong, Dept Obstet & Gynecol, Pokfulam, Hong Kong, Peoples R China
Tsang, PCK
;
Yip, AMW
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机构:
Univ Hong Kong, Dept Obstet & Gynecol, Pokfulam, Hong Kong, Peoples R ChinaUniv Hong Kong, Dept Obstet & Gynecol, Pokfulam, Hong Kong, Peoples R China
Yip, AMW
;
Tam, KF
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h-index: 0
机构:
Univ Hong Kong, Dept Obstet & Gynecol, Pokfulam, Hong Kong, Peoples R ChinaUniv Hong Kong, Dept Obstet & Gynecol, Pokfulam, Hong Kong, Peoples R China
Tam, KF
;
Wong, LC
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机构:
Univ Hong Kong, Dept Obstet & Gynecol, Pokfulam, Hong Kong, Peoples R ChinaUniv Hong Kong, Dept Obstet & Gynecol, Pokfulam, Hong Kong, Peoples R China
Wong, LC
;
Ng, TY
论文数: 0引用数: 0
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Univ Hong Kong, Dept Obstet & Gynecol, Pokfulam, Hong Kong, Peoples R ChinaUniv Hong Kong, Dept Obstet & Gynecol, Pokfulam, Hong Kong, Peoples R China
Ng, TY
;
Ngan, HYS
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机构:
Univ Hong Kong, Dept Obstet & Gynecol, Pokfulam, Hong Kong, Peoples R ChinaUniv Hong Kong, Dept Obstet & Gynecol, Pokfulam, Hong Kong, Peoples R China
机构:
Univ Hong Kong, Dept Obstet & Gynecol, Pokfulam, Hong Kong, Peoples R ChinaUniv Hong Kong, Dept Obstet & Gynecol, Pokfulam, Hong Kong, Peoples R China
Yang, HJ
;
Liu, VWS
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hong Kong, Dept Obstet & Gynecol, Pokfulam, Hong Kong, Peoples R ChinaUniv Hong Kong, Dept Obstet & Gynecol, Pokfulam, Hong Kong, Peoples R China
Liu, VWS
;
Tsang, PCK
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hong Kong, Dept Obstet & Gynecol, Pokfulam, Hong Kong, Peoples R ChinaUniv Hong Kong, Dept Obstet & Gynecol, Pokfulam, Hong Kong, Peoples R China
Tsang, PCK
;
Yip, AMW
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hong Kong, Dept Obstet & Gynecol, Pokfulam, Hong Kong, Peoples R ChinaUniv Hong Kong, Dept Obstet & Gynecol, Pokfulam, Hong Kong, Peoples R China
Yip, AMW
;
Tam, KF
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hong Kong, Dept Obstet & Gynecol, Pokfulam, Hong Kong, Peoples R ChinaUniv Hong Kong, Dept Obstet & Gynecol, Pokfulam, Hong Kong, Peoples R China
Tam, KF
;
Wong, LC
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hong Kong, Dept Obstet & Gynecol, Pokfulam, Hong Kong, Peoples R ChinaUniv Hong Kong, Dept Obstet & Gynecol, Pokfulam, Hong Kong, Peoples R China
Wong, LC
;
Ng, TY
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hong Kong, Dept Obstet & Gynecol, Pokfulam, Hong Kong, Peoples R ChinaUniv Hong Kong, Dept Obstet & Gynecol, Pokfulam, Hong Kong, Peoples R China
Ng, TY
;
Ngan, HYS
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hong Kong, Dept Obstet & Gynecol, Pokfulam, Hong Kong, Peoples R ChinaUniv Hong Kong, Dept Obstet & Gynecol, Pokfulam, Hong Kong, Peoples R China