γ-irradiated chitosan-polyvinyl pyrrolidone hydrogels as pH-sensitive protein delivery system

被引：45

作者：

Dergunov, Sergey A. ^{[1
]}

Mun, Grigody A. ^{[1
]}

机构：

[1] Kazakh Natl Univ, Dept Chem Phys & Macromol Chem, Alma Ata 050012, Kazakhstan

来源：

RADIATION PHYSICS AND CHEMISTRY | 2009年 / 78卷 / 01期

关键词：

Hydrogel; Chitosan; Polyvinyl pyrrolidone; Protein adsorption; Controlled release; POLY(ACRYLIC ACID)-CHITOSAN HYDROGELS; IN-VITRO; RADIATION SYNTHESIS; CONTROLLED RELEASE; SWELLING BEHAVIOR; ORAL DELIVERY; TRANSPORT; MEMBRANES; POLYMER; CHITIN;

D O I：

10.1016/j.radphyschem.2008.07.003

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070305 [高分子化学与物理];

摘要：

The effects of pH of the buffer solution and the composition of the hydrogel system on the bovine serum albumin (BSA) adsorption capacity of chitosan (CS)-polyvinyl pyrrolidone (PVP) (CSPVP) hydrogels and release of BSA were investigated. Poly-electrolyte CSPVP hydrogels with different compositions were prepared by irradiating CS/PVP/water mixtures with gamma-rays at ambient temperature. The adsorption capacity of hydrogels was found to increase from 0 to 350 mg BSA/g dry gel, by changing external Stimuli and hydrogel composition. The adsorption of BSA within CSPVP hydrogels increased with increase in CS content in the hydrogels. When the irradiation doses of hydrogel increased, the adsorption of BSA decreased. The maximum adsorption of BSA was observed at pH 5. A significant amount of the adsorbed BSA (up to 95%) was eluted in the phosphate medium containing 0.1 M NaCl at pH 7.4. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：65 / 68

页数：4

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