The Microbiome and Inflammatory Bowel Disease: Is There a Therapeutic Role for Fecal Microbiota Transplantation?

被引：160

作者：

Damman, Christopher J. ^{[1
]}

Miller, Samuel I. ^{[2
,3
,4
]}

Surawicz, Christina M. ^{[1
]}

Zisman, Timothy L. ^{[1
]}

机构：

[1] Univ Washington, Dept Med, Div Gastroenterol, Seattle, WA 98195 USA

[2] Univ Washington, Dept Immunol, Seattle, WA 98195 USA

[3] Univ Washington, Dept Microbiol, Seattle, WA 98195 USA

[4] Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA

来源：

AMERICAN JOURNAL OF GASTROENTEROLOGY | 2012年 / 107卷 / 10期

关键词：

GUT MICROBIOTA; ULCERATIVE-COLITIS; CROHNS-DISEASE; INTESTINAL MICROBIOTA; COLONIC MICROBIOTA; MICROFLORA; DIVERSITY; COMMENSAL; SUSCEPTIBILITY; ENTEROCOLITIS;

D O I：

10.1038/ajg.2012.93

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

One hypothesis for the etiology of inflammatory bowel disease is that an altered or pathogenic microbiota causes inflammation in a genetically susceptible individual. Understanding the microbiota's role in the pathogenesis of the disease could lead to new IBD treatments aimed at shifting the bacteria in the gut back to eubiosis. Probiotics have some efficacy in the treatment of ulcerative colitis (UC), but our current repertoire is limited in potency. Fecal microbiota therapy (FMT) is an emerging treatment for several gastrointestinal and metabolic disorders. It has demonstrated efficacy in treating refractory Clostridium difficile infection, and there are case reports of FMT successfully treating UC. Further clinical studies are justified, and could be complemented by mouse models of fecal transplantation, in which variables can be controlled and manipulated.

引用

页码：1452 / 1459

页数：8

共 102 条

[1]

Alpert C, 2008, CURR ISSUES MOL BIOL, V10, P17

[2] Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47 [J].

Anderson, Carl A. ;

Boucher, Gabrielle ;

Lees, Charlie W. ;

Franke, Andre ;

D'Amato, Mauro ;

Taylor, Kent D. ;

Lee, James C. ;

Goyette, Philippe ;

Imielinski, Marcin ;

Latiano, Anna ;

Lagace, Caroline ;

Scott, Regan ;

Amininejad, Leila ;

Bumpstead, Suzannah ;

Baidoo, Leonard ;

Baldassano, Robert N. ;

Barclay, Murray ;

Bayless, Theodore M. ;

Brand, Stephan ;

Buening, Carsten ;

Colombel, Jean-Frederic ;

Denson, Lee A. ;

De Vos, Martine ;

Dubinsky, Marla ;

Edwards, Cathryn ;

Ellinghaus, David ;

Fehrmann, Rudolf S. N. ;

Floyd, James A. B. ;

Florin, Timothy ;

Franchimont, Denis ;

Franke, Lude ;

Georges, Michel ;

Glas, Juergen ;

Glazer, Nicole L. ;

Guthery, Stephen L. ;

Haritunians, Talin ;

Hayward, Nicholas K. ;

Hugot, Jean-Pierre ;

Jobin, Gilles ;

Laukens, Debby ;

Lawrance, Ian ;

Lemann, Marc ;

Levine, Arie ;

Libioulle, Cecile ;

Louis, Edouard ;

McGovern, Dermot P. ;

Milla, Monica ;

Montgomery, Grant W. ;

Morley, Katherine I. ;

Mowat, Craig .

NATURE GENETICS, 2011, 43 (03) :246-U94

[3] The Struggle Within: Microbial Influences on Colorectal Cancer [J].

Arthur, Janelle C. ;

Jobin, Christian .

INFLAMMATORY BOWEL DISEASES, 2011, 17 (01) :396-409

[4] Enterotypes of the human gut microbiome [J].

Arumugam, Manimozhiyan ;

Raes, Jeroen ;

Pelletier, Eric ;

Le Paslier, Denis ;

Yamada, Takuji ;

Mende, Daniel R. ;

Fernandes, Gabriel R. ;

Tap, Julien ;

Bruls, Thomas ;

Batto, Jean-Michel ;

Bertalan, Marcelo ;

Borruel, Natalia ;

Casellas, Francesc ;

Fernandez, Leyden ;

Gautier, Laurent ;

Hansen, Torben ;

Hattori, Masahira ;

Hayashi, Tetsuya ;

Kleerebezem, Michiel ;

Kurokawa, Ken ;

Leclerc, Marion ;

Levenez, Florence ;

Manichanh, Chaysavanh ;

Nielsen, H. Bjorn ;

Nielsen, Trine ;

Pons, Nicolas ;

Poulain, Julie ;

Qin, Junjie ;

Sicheritz-Ponten, Thomas ;

Tims, Sebastian ;

Torrents, David ;

Ugarte, Edgardo ;

Zoetendal, Erwin G. ;

Wang, Jun ;

Guarner, Francisco ;

Pedersen, Oluf ;

de Vos, Willem M. ;

Brunak, Soren ;

Dore, Joel ;

Weissenbach, Jean ;

Ehrlich, S. Dusko ;

Bork, Peer .

NATURE, 2011, 473 (7346) :174-180

[5] Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species [J].

Atarashi, Koji ;

Tanoue, Takeshi ;

Shima, Tatsuichiro ;

Imaoka, Akemi ;

Kuwahara, Tomomi ;

Momose, Yoshika ;

Cheng, Genhong ;

Yamasaki, Sho ;

Saito, Takashi ;

Ohba, Yusuke ;

Taniguchi, Tadatsugu ;

Takeda, Kiyoshi ;

Hori, Shohei ;

Ivanov, Ivaylo I. ;

Umesaki, Yoshinori ;

Itoh, Kikuji ;

Honda, Kenya .

SCIENCE, 2011, 331 (6015) :337-341

[6] Host-bacterial mutualism in the human intestine [J].

Bäckhed, F ;

Ley, RE ;

Sonnenburg, JL ;

Peterson, DA ;

Gordon, JI .

SCIENCE, 2005, 307 (5717) :1915-1920

[7] Treating Clostridium difficile Infection With Fecal Microbiota Transplantation [J].

Bakken, Johan S. ;

Borody, Thomas ;

Brandt, Lawrence J. ;

Brill, Joel V. ;

Demarco, Daniel C. ;

Franzos, Marc Alaric ;

Kelly, Colleen ;

Khoruts, Alexander ;

Louie, Thomas ;

Martinelli, Lawrence P. ;

Moore, Thomas A. ;

Russell, George ;

Surawicz, Christina .

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2011, 9 (12) :1044-1049

[8]

BENNET JD, 1989, LANCET, V1, P164

[9] Fecal microbiota transplantation and emerging applications [J].

Borody, Thomas J. ;

Khoruts, Alexander .

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2012, 9 (02) :88-96

[10]

Borody TJ, 2011, EXPERT REV GASTROENT, V5, P653, DOI [10.1586/EGH.11.71, 10.1586/egh.11.71]

← 1 2 3 4 5 6 7 8 9 10 →