Treating Clostridium difficile Infection With Fecal Microbiota Transplantation

被引：749

作者：

Bakken, Johan S. ^{[1
]}

Borody, Thomas

Brandt, Lawrence J. ^{[2
]}

Brill, Joel V. ^{[3
]}

Demarco, Daniel C. ^{[4
]}

Franzos, Marc Alaric ^{[5
]}

Kelly, Colleen ^{[6
]}

Khoruts, Alexander ^{[7
,8
]}

Louie, Thomas ^{[9
]}

Martinelli, Lawrence P. ^{[13
]}

Moore, Thomas A. ^{[10
]}

Russell, George ^{[11
]}

Surawicz, Christina ^{[12
]}

机构：

[1] St Lukes Infect Dis Associates, Duluth, MN USA

[2] Albert Einstein Coll Med, Montefiore Med Ctr, Div Gastroenterol, New York, NY USA

[3] Predict Hlth LLC, Phoenix, AZ USA

[4] Baylor Univ, Med Ctr, Dallas, TX USA

[5] Marine Aircraft Grp 24, Kaneohe Bay, HI USA

[6] Brown Univ, Women & Infants Hosp, Providence, RI USA

[7] Univ Minnesota, Dept Med, Minneapolis, MN 55455 USA

[8] Univ Minnesota, Ctr Immunol, Minneapolis, MN USA

[9] Univ Calgary, Calgary, AB T2N 1N4, Canada

[10] Ochsner Hlth Syst, Dept Infect Dis, New Orleans, LA USA

[11] Massachusetts Gen Hosp Children, Boston, MA USA

[12] Univ Washington, Sch Med, Dept Med, Div Gastroenterol, Seattle, WA 98195 USA

[13] Consultants Infect Dis, Lubbock, TX USA

来源：

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY | 2011年 / 9卷 / 12期

关键词：

Clostridium difficile; Transplantation; Microbiota; Fecal Enema; Recurrent Infection; Diarrhea; PLACEBO-CONTROLLED TRIAL; SACCHAROMYCES-BOULARDII; TREATMENT STRATEGIES; CASE SERIES; DISEASE; DIARRHEA; EPIDEMIOLOGY; ENTEROCOLITIS; VANCOMYCIN; SEVERITY;

D O I：

10.1016/j.cgh.2011.08.014

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Clostridium difficile infection is increasing in incidence, severity, and mortality. Treatment options are limited and appear to be losing efficacy. Recurrent disease is especially challenging; extended treatment with oral vancomycin is becoming increasingly common but is expensive. Fecal microbiota transplantation is safe, inexpensive, and effective; according to case and small series reports, about 90% of patients are cured. We discuss the rationale, methods, and use of fecal microbiota transplantation.

引用

页码：1044 / 1049

页数：6

共 31 条

[1] Recurrent Clostridium difficile colitis:: Case series involving 18 patients treated with donor stool administered via a nasogastric tube [J].