Decreased diversity of the fecal microbiome in recurrent Clostridium difficile-associated diarrhea

被引：777

作者：

Chang, Ju Young ^{[2
]}

Antonopoulos, Dionysios A. ^{[2
]}

Kalra, Apoorv ^{[4
]}

Tonelli, Adriano ^{[4
]}

Khalife, Walid T. ^{[3
]}

Schmidt, Thomas M. ^{[2
]}

Young, Vincent B. ^{[1
,2
,4
,5
]}

机构：

[1] Univ Michigan, Div Infect Dis, Ann Arbor, MI 48109 USA

[2] Michigan State Univ, Dept Microbiol & Mol Genet, E Lansing, MI 48824 USA

[3] Michigan State Univ, Med Technol Program, E Lansing, MI 48824 USA

[4] Michigan State Univ, Infect Dis Unit, Dept Internal Med, E Lansing, MI 48824 USA

[5] Michigan State Univ, Natl Food Safety & Toxicol Ctr, E Lansing, MI 48824 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2008年 / 197卷 / 03期

关键词：

D O I：

10.1086/525047

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Antibiotic-associated diarrhea due to Clostridium difficile (CDAD) is thought to reflect colonization of a disrupted microbial community by the pathogen. We profiled the fecal microbiota of patients with CDAD (both initial and recurrent episodes) by culture-independent phylogenetic analysis of 16S rRNA-encoding gene sequences. Compared with those from control subjects and patients with an initial episode, the fecal communities in patients with recurrent CDAD were highly variable in bacterial composition and were characterized by markedly decreased diversity. Preservation and restoration of the microbial diversity could represent novel strategies for prevention and treatment of recurrent CDAD, which is often recalcitrant to existing therapies.

引用

页码：435 / 438

页数：4

共 15 条

[1] Recurrent Clostridium difficile colitis:: Case series involving 18 patients treated with donor stool administered via a nasogastric tube [J].

Aas, J ;

Gessert, CE ;

Bakken, JS .

CLINICAL INFECTIOUS DISEASES, 2003, 36 (05) :580-585

[2] Antibiotic-associated diarrhea [J].

Bartlett, JG .

NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (05) :334-339

[3] Interruption of recurrent Clostridium difficile -: Associated diarrhea episodes by serial therapy with vancomycin and rifaximin [J].

Johnson, Stuart ;

Schriever, Christopher ;

Galang, Minerva ;

Kelly, Ciaran P. ;

Gerding, Dale N. .

CLINICAL INFECTIOUS DISEASES, 2007, 44 (06) :846-848

[4] Association between antibody response to toxin A and protection against recurrent Clostridium difficile diarrhoea [J].

Kyne, L ;

Warny, M ;

Qamar, A ;

Kelly, CP .

LANCET, 2001, 357 (9251) :189-193

[5] Ecological and evolutionary forces shaping microbial diversity in the human intestine [J].

Ley, RE ;

Peterson, DA ;

Gordon, JI .

CELL, 2006, 124 (04) :837-848

[6]

Magurran AE., 2004, MEASURING BIOL DIVER

[7] Recurrent Clostridium difficile [J].

Maroo, S ;

Lamont, JT .

GASTROENTEROLOGY, 2006, 130 (04) :1311-1316

[8] Breaking the cycle:: Treatment strategies for 163 cases of recurrent Clostridium difficile disease [J].

McFarland, LV ;

Elmer, GW ;

Surawicz, CM .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2002, 97 (07) :1769-1775

[9] Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of Clostridium difficile disease [J].

McFarland, LV .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2006, 101 (04) :812-822

[10] Introducing DOTUR, a computer program for defining operational taxonomic units and estimating species richness [J].

Schloss, PD ;

Handelsman, J .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2005, 71 (03) :1501-1506

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