Imaging without lenses: achievements and remaining challenges of wide-field on-chip microscopy

被引：453

作者：

Greenbaum, Alon ^{[1
,2
]}

Luo, Wei ^{[1
,2
]}

Su, Ting-Wei ^{[1
,2
]}

Goeroecs, Zoltan ^{[1
,2
]}

Xue, Liang ^{[1
,2
,3
]}

Isikman, Serhan O. ^{[1
,2
]}

Coskun, Ahmet F. ^{[1
,2
]}

Mudanyali, Onur ^{[1
,2
]}

Ozcan, Aydogan ^{[1
,2
,4
,5
]}

机构：

[1] Univ Calif Los Angeles, Dept Elect Engn, Los Angeles, CA 90024 USA

[2] Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90024 USA

[3] Nanjing Univ Sci & Technol, Dept Informat Phys & Engn, Nanjing, Jiangsu, Peoples R China

[4] Univ Calif Los Angeles, David Geffen Sch Med, Dept Surg, Los Angeles, CA 90024 USA

[5] Univ Calif Los Angeles, California NanoSyst Inst, Los Angeles, CA 90024 USA

来源：

NATURE METHODS | 2012年 / 9卷 / 09期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

LINE HOLOGRAPHIC MICROSCOPY; PHASE RETRIEVAL; DIGITAL HOLOGRAPHY; PIXEL SUPERRESOLUTION; RESOLUTION; RECONSTRUCTION; TOMOGRAPHY; PLATFORM; CRYSTALLOGRAPHY; PTYCHOGRAPHY;

D O I：

10.1038/nmeth.2114

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We discuss unique features of lens-free computational imaging tools and report some of their emerging results for wide-field on-chip microscopy, such as the achievement of a numerical aperture (NANA) of similar to 0.8-0.9 across a field of view (FOV) of more than 20 mm(2) or an NANA of similar to 0.1 across a FOV of similar to 18 cm(2), which corresponds to an image with more than 1.5 gigapixels. We also discuss the current challenges that these computational on-chip microscopes face, shedding light on their future directions and applications.

引用

页码：889 / 895

页数：7

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