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Non-thiol 3-aminomethylbenzamide inhibitors of farnesyl-protein transferase

被引：34
作者：
Ciccarone, TM
MacTough, SC
Williams, TM
Dinsmore, CJ
O'Neill, TJ
Shah, D
Culberson, JC
Koblan, KS
Kohl, NE
Gibbs, JB
Oliff, AI
Graham, SL
Hartman, GD
机构：
[1] Merck Res Labs, Dept Med Chem, W Point, PA 19486 USA
[2] Merck Res Labs, Dept Canc Res, W Point, PA 19486 USA
[3] Merck Res Labs, Dept Mol Syst, W Point, PA 19486 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 14期
关键词：
D O I：
10.1016/S0960-894X(99)00323-6
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The design and syntheses of non-thiol inhibitors of farnesyl-protein transferase are described. Substitutions on an imidazolylmethyl-AMBA-methionine template gave a highly potent and cell active inhibitor. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1991 / 1996
页数：6
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