Benzamide-type vanilloid (TRPV1) antagonists

被引：2

作者：

Appendino, G ^{[1
]}

机构：

[1] Dipartimento Sci Chim Alimentari Farmaceut & Farm, I-10131 Novara, Italy

来源：

EXPERT OPINION ON THERAPEUTIC PATENTS | 2006年 / 16卷 / 04期

关键词：

inflammation; pain management; TRP-channel; TRPV1 I inhibitor; vanilloid receptor;

D O I：

10.1517/13543776.16.4.549

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Pfizer claims vanilloid receptor TRPV1 inhibitory activity for a series of compounds based on a N-benzoyl-beta-(tetrahydronaphthalenyl)ethylamine core structure. These amides are similar to a series of N-tetrahydronaphthalenyl-N'-benzylureas and Wetheroaryl-N'-benzylureas previously described. Potential therapeutic application in a variety of diseases such as chronic pain, neuropathies, headache, bladder disorders, irritable bowel disease and cough is claimed.

引用

页码：549 / 553

页数：5

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