Apoptosis in human and rat dental pulp

被引：52

作者：

Vermelin, L ^{[1
]}

Lecolle, S ^{[1
]}

Septier, D ^{[1
]}

Lasfargues, JJ ^{[1
]}

Goldberg, M ^{[1
]}

机构：

[1] FAC CHIRURG DENT PARIS 5, LAB BIOL & BIOMAT MILIEU BUCCAL & OSSEUX, EA 1505, F-92120 MONTROUGE, FRANCE

来源：

EUROPEAN JOURNAL OF ORAL SCIENCES | 1996年 / 104卷 / 5-6期

关键词：

apoptosis; pulp cells; terminal deoxynucleotidylytransferase-mediated nick end labeling; anti-transglutaminase;

D O I：

10.1111/j.1600-0722.1996.tb00140.x

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Apoptotic cells were visualized in human premolar and rat molar pulps using either the TUNEL method, which stains DNA strand breaks by ill situ nick end labeling, or labeling sections with an anti-transglutaminase antibody. Apoptotic cells were evident at the periphery of the pulp, mostly in a sub-odontoblastic location, and were more numerous in the crown than in the root region of the pulp. Most odontoblasts were unlabeled. A few apoptotic nuclei in the pulp of rat molars displayed the characteristics of chromatin condensation, as observed by electron microscopy. Many cell debris resembling apoptotic bodies were also observed. The 3 methods support the occurrence of apoptosis in the dental pulp. As this phenomenon was observed in healthy teeth, apoptosis is probably involved in the regulation of the pulp cell population.

引用

页码：547 / 553

页数：7

共 29 条

[21] THE RELATIONSHIP BETWEEN ODONTOBLASTS AND IMMUNOCOMPETENT CELLS DURING DENTINOGENESIS IN RAT INCISORS - AN IMMUNOHISTOCHEMICAL STUDY USING OX6-MONOCLONAL ANTIBODY [J].