Tandem conjugate cyanide addition-Dieckmann condensation in the synthesis of the ABCD-ring system of lactonamycin

被引：42

作者：

Deville, JP ^{[1
]}

Behar, V ^{[1
]}

机构：

[1] Rice Univ, Dept Chem, Houston, TX 77251 USA

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 08期

关键词：

D O I：

10.1021/ol0257373

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] An efficient synthesis of the ABCD-ring system of lactonamycin (1) is reported in this Letter. The key step is the tandem cyanide conjugate addition-Dieckmann condensation of alkyne 17 to afford a fully functionalized anthracene. Selective reduction of the cyano group with subsequent lectern formation affords the tetracyclic core of lactonamycin 19.

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页码：1403 / 1405

页数：3

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