Regulation of hematopoietic stem cells by bone marrow stromal cells

被引：259

作者：

Anthony, Bryan A. ^{[1
]}

Link, Daniel C. ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Med, Siteman Canc Ctr, St Louis, MO 63110 USA

来源：

TRENDS IN IMMUNOLOGY | 2014年 / 35卷 / 01期

基金：

美国国家卫生研究院;

关键词：

hematopoietic stem cells; stem cell niche; mesenchymal stem cells; osteoblasts; CXCL12; N-CADHERIN; IN-VIVO; PROGENITOR CELLS; AORTIC ENDOTHELIUM; STIMULATING FACTOR; VASCULAR NICHE; SELF-RENEWAL; CXCR4; MAINTENANCE; ENGRAFTMENT;

D O I：

10.1016/j.it.2013.10.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Hematopoietic stem cells (HSCs) reside in specialized microenvironments (niches) in the bone marrow. The stem cell niche is thought to provide signals that support key HSC properties, including self-renewal capacity and long-term multilineage repopulation ability. The stromal cells that comprise the stem cell niche and the signals that they generate that support HSC function are the subjects of intense investigation. Here, we review the complex and diverse stromal cell populations that reside in the bone marrow and examine their contribution to HSC maintenance. We highlight recent data suggesting that perivascular chemokine CXC ligand (CXCL)12-expressing mesenchymal progenitors and endothelial cells are key cellular components of the stem cell niche in the bone marrow.

引用

页码：32 / 37

页数：6

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