Penetration, adhesion, and fusion in mammalian sperm-egg interaction

被引：255

作者：

Primakoff, P ^{[1
]}

Myles, DG

机构：

[1] Univ Calif Davis, Sch Med, Dept Cell Biol, Davis, CA 95616 USA

[2] Univ Calif Davis, Sect Mol & Cell Biol, Davis, CA 95616 USA

来源：

SCIENCE | 2002年 / 296卷 / 5576期

关键词：

D O I：

10.1126/science.1072029

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Fertilization is the sum of the cellular mechanisms that pass the genome from one generation to the next and initiate development of a new organism. A typical, ovulated mammalian egg is enclosed by two layers: an outer layer of similar to5000 cumulus cells and an inner, thick extracellular matrix, the zona pellucida. To reach the egg plasma membrane, sperm must penetrate both layers in steps requiring sperm motility, sperm surface enzymes, and probably sperm-secreted enzymes. Sperm also bind transiently to the egg zona pellucida and the egg plasma membrane and then fuse. Signaling in the sperm is induced by sperm adhesion to the zona pellucida, and signaling in the egg by gamete fusion. The gamete molecules and molecular interactions with essential roles in these events are gradually being discovered.

引用

页码：2183 / 2185

页数：4

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