The regulation of cell migration by PTEN

被引：43

作者：

Leslie, NR ^{[1
]}

Yang, X

Downes, CP

Weijer, CJ

机构：

[1] Univ Dundee, Div Mol Physiol, Dundee DD1 5EH, Scotland

[2] Univ Dundee, Div Cell & Dev Biol, Dundee DD1 5EH, Scotland

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2005年 / 33卷

关键词：

cell migration; chemoattractant; lipid phosphatase; phosphoinositide 3-kinase (PI3K); Ptdlns(3,4,5)P-3; phosphatase and tensin homologue deleted on chromosome 10 (PTEN);

D O I：

10.1042/BST0331507

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In vertebrates, the tumour suppressor PTEN (phosphatase and tensin homologue deleted on chromosome 10) regulates many cellular processes through its PtdIns(3,4,5)P-3 lipid phosphatase activity, antagonizing PI3K (phosphoinositide 3-kinase) signalling. Given the important role of PI3Ks in the regulation of directed cell migration and the role of PTEN as an inhibitor of migration, it is somewhat surprising that data now indicate that PTEN is able to regulate cell migration independent of its lipid phosphatase activity. Here, we discuss the role of PTEN in the regulation of cell migration.

引用

页码：1507 / 1508

页数：2

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