Obesity, immunomodulation and chronic kidney disease

被引：28

作者：

Boergeson, Emma ^{[1
]}

Sharma, Kumar ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Med, Inst Metab Med, Ctr Renal Translat Med,Div Nephrol Hypertens, La Jolla, CA 92093 USA

来源：

CURRENT OPINION IN PHARMACOLOGY | 2013年 / 13卷 / 04期

关键词：

ADIPOSE-TISSUE MACROPHAGES; RESOLVIN D1; ACUTE-INFLAMMATION; INSULIN SENSITIVITY; HUMAN PHAGOCYTES; LIPID MEDIATORS; GENE-EXPRESSION; LIPOXIN A(4); FATTY-ACIDS; RESOLUTION;

D O I：

10.1016/j.coph.2013.05.011

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Obesity-induced inflammation is associated with numerous pathologies and is an independent risk factor of chronic kidney disease (CKD). The prevalence of CKD is escalating and current therapeutic strategies are seriously lacking in efficacy, and immunomodulation has been suggested as a potential new therapeutic approach. Indeed, specialized pro-resolving mediators (SPMs), such as lipoxins (LXs), resolvins and protectins, have demonstrated protection in adipose inflammation, restoring insulin sensitivity and adiponectin production, while modulating leukocyte infiltration and promoting resolution in visceral adipose tissue. Furthermore, SPMs display direct renoprotective effect. Thus we review current evidence of immunomodulation as a potential strategy to subvert obesity-related CKD.

引用

页码：618 / 624

页数：7

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