Cytokine-mediated regulation of antimicrobial proteins

被引：288

作者：

Kolls, Jay K. ^{[1
]}

McCray, Paul B., Jr. ^{[2
]}

Chan, Yvonne R. ^{[3
]}

机构：

[1] Univ Pittsburgh, Childrens Hosp Pittsburgh, Dept Pediat, Pittsburgh, PA 15213 USA

[2] Univ Iowa, Carver Coll Med, Dept Pediat, Div Allergy & Pulmonol, Iowa City, IA 52242 USA

[3] Univ Pittsburgh, Div Pulm Allergy & Crit Care Med, Pittsburgh, PA 15213 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2008年 / 8卷 / 11期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nri2433

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Antimicrobial proteins constitute a phylogenetically ancient form of innate immunity that provides host defence at skin and mucosal surfaces. Although some components of this system are constitutively expressed, new evidence reviewed in this Progress article shows that the production of certain antimicrobial proteins by epithelial cells can also be regulated by cytokines of the innate and adaptive immune systems. In particular, the effector cytokines interleukin-17 and interleukin-22, which are produced by the T-helper-17-cell subset, are emerging as crucial regulators of antimicrobial-peptide production in the gut and the lungs. This suggests that this T-cell lineage and its cytokines have important roles in skin and mucosal immunity.

引用

页码：829 / 835

页数：7

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