Synthesis of pyranonaphthoquinone antibiotics involving the phthalide annulation strategy

被引：18

作者：

Claessens, S

Naidoo, D

Mulholland, D

Verschaeve, L

van Staden, J

De Kimpe, N

机构：

[1] Univ Ghent, Fac Biosci Engn, Dept Organ Chem, B-9000 Ghent, Belgium

[2] Univ KwaZulu Natal, Sch Chem, ZA-4041 Durban, South Africa

[3] Vlaamse Instelling Technol Onderzoek, Flemish Inst Technol Res, Dept Environm Toxicol, B-2400 Mol, Belgium

[4] Univ KwaZulu Natal, Sch Bot & Zool, Res Ctr Plant Growth & Deb, ZA-3209 Scottsville, South Africa

来源：

SYNLETT | 2006年 / 04期

关键词：

annulations; natural products; quinones; phthalide; pentalongin;

D O I：

10.1055/s-2006-926248

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

The synthesis of the pyranonaphthoquinone antibiotic pentalongin was performed using the phthalide annulation strategy. Annulation of the cyanophthialide onto 6H-pyran-3-one resulted in a hongconin analogue, which Upon further elaboration was converted into the natural product.

引用

收藏

页码：621 / 623

页数：3

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