Glutamate transmission in addiction

被引：257

作者：

Kalivas, Peter W. ^{[1
]}

LaLumiere, Ryan T. ^{[1
]}

Knackstedt, Lori ^{[1
]}

Shen, Haowei ^{[1
]}

机构：

[1] Med Univ S Carolina, Dept Neurosci, Charleston, SC 29464 USA

来源：

NEUROPHARMACOLOGY | 2009年 / 56卷

关键词：

Glutamate; Sensitization; Drug-seeking; Ventral tegmental area; Nucleus accumbens; VENTRAL TEGMENTAL AREA; COCAINE-INDUCED REINSTATEMENT; NUCLEUS-ACCUMBENS CORE; CORTICOTROPIN-RELEASING-FACTOR; STRESS-INDUCED RELAPSE; LONG-TERM DEPRESSION; CRF-BINDING-PROTEIN; BEHAVIORAL SENSITIZATION; SEEKING BEHAVIOR; SYNAPTIC PLASTICITY;

D O I：

10.1016/j.neuropharm.2008.07.011

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cortico-striatal glutamate transmission has been implicated in both the initiation and expression of addiction related behaviors, such as locornotor sensitization and drUg-seeking. While glUtarnate transmission onto dopamine cells in the ventral tegmental area undergoes transient plasticity important for establishing addiction-related behaviors, glutamatergic plasticity in the nucleus accumbens is critical for the expression of these behaviors. This information points to the value of exploring pharmacotherapeutic manipulation of glutamate plasticity in treating drug addiction. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：169 / 173

页数：5

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