Stabilizers and destabilizers controlling cell cycle oscillators

被引:71
作者
Guardavaccaro, D
Pagano, M
机构
[1] NYU, Inst Canc, Dept Pathol, New York, NY 10016 USA
[2] NYU, Sch Med, Emerald Fdn, New York, NY 10016 USA
关键词
D O I
10.1016/j.molcel.2006.03.017
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Various destabilizing factors of the ubiquitin system contribute to the synchrony and unidirectionality of the cell cycle clock by finely tuning the activity of various CDKs. The recent findings of hierarchical and connected waves of cyclin stabilizers highlight the complexity of this network.
引用
收藏
页码:1 / 4
页数:4
相关论文
共 19 条
  • [1] ANG XL, 2004, SCI STKE, V228, pPE31
  • [2] Cdk1: the dominant sibling of Cdk2
    Bashir, T
    Pagano, M
    [J]. NATURE CELL BIOLOGY, 2005, 7 (08) : 779 - 781
  • [3] Mitotic-exit control as an evolved complex system
    Bosl, WJ
    Li, R
    [J]. CELL, 2005, 121 (03) : 325 - 333
  • [4] The SCF ubiquitin ligase: Insights into a molecular machine
    Cardozo, T
    Pagano, M
    [J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2004, 5 (09) : 739 - 751
  • [5] EVI5 is a novel centrosomal protein that binds to α- and γ-tubulin
    Faitar, SL
    Dabbeekeh, JTS
    Ranalli, TA
    Cowell, JK
    [J]. GENOMICS, 2005, 86 (05) : 594 - 605
  • [6] Control of meiotic and mitotic progression by the F box protein β-Trcp1 in vivo
    Guardavaccaro, D
    Kudo, Y
    Boulaire, J
    Barchi, M
    Busino, L
    Donzelli, M
    Margottin-Goguet, F
    Jackson, PK
    Yamasaki, L
    Pagano, M
    [J]. DEVELOPMENTAL CELL, 2003, 4 (06) : 799 - 812
  • [7] E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APCCdh1
    Hsu, JY
    Reimann, JDR
    Sorensen, CS
    Lukas, J
    Jackson, PK
    [J]. NATURE CELL BIOLOGY, 2002, 4 (05) : 358 - 366
  • [8] Crashing waves of destruction:: The cell cycle and APCCdh1 regulation of SCFSkp2
    Kurland, JF
    Tansey, WP
    [J]. CANCER CELL, 2004, 5 (04) : 305 - 306
  • [9] Proviral integrations at the Evi5 locus disrupt a novel 90 kDa protein with homology to the Tre2 oncogene and cell-cycle regulatory proteins
    Liao, XB
    Du, YB
    Morse, HC
    Jenkins, NA
    Copeland, NG
    [J]. ONCOGENE, 1997, 14 (09) : 1023 - 1029
  • [10] Cell division - The heart of the cycle
    Lukas, J
    Bartek, J
    [J]. NATURE, 2004, 432 (7017) : 564 - +