Quiescent Tissue Stem Cells Evade Immune Surveillance

被引：207

作者：

Agudo, Judith ^{[1
,2
]}

Park, Eun Sook ^{[2
]}

Rose, Samuel A. ^{[2
]}

Alibo, Eziwoma ^{[1
,2
]}

Sweeney, Robert ^{[2
]}

Dhainaut, Maxime ^{[1
,2
]}

Kobayashi, Koichi S. ^{[4
]}

Sachidanandam, Ravi ^{[3
,5
]}

Baccarini, Alessia ^{[2
]}

Merad, Miriam ^{[1
,3
,5
]}

Brown, Brian D. ^{[1
,2
,3
]}

机构：

[1] Icahn Sch Med Mt Sinai, Precis Immunol Inst, New York, NY 10029 USA

[2] Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA

[3] Icahn Sch Med Mt Sinai, Tisch Canc Inst, New York, NY 10029 USA

[4] Hokkaido Univ, Fac Med, Sapporo, Hokkaido 0608638, Japan

[5] Icahn Sch Med Mt Sinai, Dept Oncol Sci, New York, NY 10029 USA

来源：

IMMUNITY | 2018年 / 48卷 / 02期

关键词：

MHC CLASS-I; T-CELLS; FUNCTIONALLY DISTINCT; SOMATIC MUTATIONS; SMALL-INTESTINE; SELF-RENEWAL; NICHE; VIVO; PRIVILEGE; CANCER;

D O I：

10.1016/j.immuni.2018.02.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Stem cells are critical for the maintenance of many tissues, but whether their integrity is maintained in the face of immunity is unclear. Here we found that cycling epithelial stem cells, including Lgr(5+) intestinal stem cells, as well as ovary and mammary stem cells, were eliminated by activated T cells, but quiescent stem cells in the hair follicle and muscle were resistant to T cell killing. Immune evasion was an intrinsic property of the quiescent stem cells resulting from systemic downregulation of the antigen presentation machinery, including MHC class I and TAP proteins, and is mediated by the transactivator NLRC5. This process was reversed upon stem cell entry into the cell cycle. These studies identify a link between stem cell quiescence, antigen presentation, and immune evasion. As cancer-initiating cells can derive from stem cells, these findings may help explain how the earliest cancer cells evade immune surveillance.

引用

页码：271 / +

页数：20

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