Type III secretion systems: Machines to deliver bacterial proteins into eukaryotic cells?

被引：174

作者：

Lee, CA

机构：

[1] Dept. Microbiol. and Molec. Genet., Harvard Medical School, Boston

来源：

TRENDS IN MICROBIOLOGY | 1997年 / 5卷 / 04期

关键词：

D O I：

10.1016/S0966-842X(97)01029-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Type III secretion systems in certain bacterial pathogens are induced upon contact with host cells and directly deliver virulence proteins into the host cell cytosol. The increasing number of Gram-negative bacterial pathogens discovered to encode type III secretion systems raises interesting questions. Are type BI systems generic machines that deliver virulence proteins into host cells? Is contact with host cells a common regulatory cue for type III systems?

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页码：148 / 156

页数：9

相关论文

共 58 条

[1] MXIG, A MEMBRANE-PROTEIN REQUIRED FOR SECRETION OF SHIGELLA SPP LPA INVASINS - INVOLVEMENT IN ENTRY INTO EPITHELIAL-CELLS AND IN INTERCELLULAR DISSEMINATION [J].

ALLAOUI, A ;

SANSONETTI, PJ ;

MENARD, R ;

BARZU, S ;

MOUNIER, J ;

PHALIPON, A ;

PARSOT, C .

MOLECULAR MICROBIOLOGY, 1995, 17 (03) :461-470

[2] MUTATIONAL ANALYSIS OF THE YERSINIA-ENTEROCOLITICA VIRC OPERON - CHARACTERIZATION OF YSCE, YSCF, YSCG, YSCI, YSCJ, YSCK REQUIRED FOR YOP SECRETION AND YSCH ENCODING YOPR [J].

ALLAOUI, A ;

SCHULTE, R ;

CORNELIS, GR .

MOLECULAR MICROBIOLOGY, 1995, 18 (02) :343-355

[3] 2 NOVEL VIRULENCE LOCI, MXIA AND MXIB, IN SHIGELLA-FLEXNERI 2A FACILITATE EXCRETION OF INVASION PLASMID ANTIGENS [J].

ANDREWS, GP ;

HROMOCKYJ, AE ;

COKER, C ;

MAURELLI, AT .

INFECTION AND IMMUNITY, 1991, 59 (06) :1997-2005

[4] THE LCRB (YSCN/U) GENE-CLUSTER OF YERSINIA-PSEUDOTUBERCULOSIS IS INVOLVED IN YOP SECRETION AND SHOWS HIGH HOMOLOGY TO THE SPA GENE CLUSTERS OF SHIGELLA-FLEXNERI AND SALMONELLA-TYPHIMURIUM [J].

BERGMAN, T ;

ERICKSON, K ;

GALYOV, E ;

PERSSON, C ;

WOLFWATZ, H .

JOURNAL OF BACTERIOLOGY, 1994, 176 (09) :2619-2626

[5] Unified nomenclature for broadly conserved hrp genes of phytopathogenic bacteria [J].

Bogdanove, AJ ;

Beer, SV ;

Bonas, U ;

Boucher, CA ;

Collmer, A ;

Coplin, DL ;

Cornelis, GR ;

Huang, HC ;

Hutcheson, SW ;

Panopoulos, NJ ;

VanGijsegem, F .

MOLECULAR MICROBIOLOGY, 1996, 20 (03) :681-683

[6] Status of YopM and YopN in the Yersinia Yop virulon: YopM of Y-enterocolitica is internalized inside the cytosol of PU5-1.8 macrophages by the YopB, D, N delivery apparatus [J].

Boland, A ;

Sory, MP ;

Iriarte, M ;

Kerbourch, C ;

Wattiau, P ;

Cornelis, GR .

EMBO JOURNAL, 1996, 15 (19) :5191-5201

[7]

Bonas U, 1994, Curr Top Microbiol Immunol, V192, P79

[8] Requirement for exported proteins in secretion through the invasion-associated type III system of Salmonella typhimurium [J].

Collazo, CM ;

Galan, JE .

INFECTION AND IMMUNITY, 1996, 64 (09) :3524-3531

[9]

Cornelis G R, 1994, Curr Top Microbiol Immunol, V192, P243

[10] Interactions between enteropathogenic Escherichia coli and host epithelial cells [J].

Donnenberg, MS ;

Kaper, JB ;

Finlay, BB .

TRENDS IN MICROBIOLOGY, 1997, 5 (03) :109-114

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