Olestra formulation and the gastrointestinal tract

被引:11
作者
Jandacek, RJ
Kester, JJ
Papa, AJ
Wehmeier, TJ
Lin, PYT
机构
[1] Procter & Gamble Co, Miami Valley Labs, Cincinnati, OH 45253 USA
[2] Procter & Gamble Co, Winton Hill Tech Ctr, Cincinnati, OH 45253 USA
关键词
D O I
10.1007/s11745-999-0423-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Olestra is a mixture of compounds comprising sucrose esterified with 6-8 long-chain fatty acids. It is not hydrolyzed by pancreatic lipase and as a result is not absorbed from the small intestine. Olestra in general has physical properties similar to those of a triacylglycerol with the same fatty acid composition. Foods made with olestra are virtually identical in taste and texture to those made with typical triacylglycerols. Olestra consumption does not generate hydrolytic products in the small intestine and, therefore, does not generate some of the signals that alter motility in the gastrointestinal tract. A reduction in gastroesophageal reflux with olestra, in contrast to triacylglycerols, is consistent with a lack of effect on stomach emptying. Unlike triacylglycerols that are absorbed in the proximal small intestine, olestra is distributed throughout the small intestine during transit and passes into the colon. in the colon, olestra's effects depend on its physical properties. Liquid nondigestible lipids result in separation of oil from the fecal matrix. Olestra formulations made with specific fatty acid compositions, particularly those containing a solid sucrose polyester component including behenic acid, possess appropriate rheology to hinder separation of oil from the rest of the fecal matrix, thereby reducing gastrointestinal symptoms.
引用
收藏
页码:771 / 783
页数:13
相关论文
共 61 条
[21]   LIQUID FOODSTUFFS EXHIBITING YIELD STRESS AND SHEAR-DEGRADABILITY [J].
HALMOS, AL ;
TIU, C .
JOURNAL OF TEXTURE STUDIES, 1981, 12 (01) :39-46
[22]  
Hamosh M., 1984, P49
[23]  
HOFMANN AF, 1962, FED PROC, V21, P43
[24]  
Jandacek R.J., 1989, U.S. Patent, Patent No. [4,797,300, 4797300]
[25]   EFFECT OF SUCROSE POLYESTER ON FECAL STEROID-EXCRETION BY 24 NORMAL MEN [J].
JANDACEK, RJ ;
MATTSON, FH ;
MCNEELY, S ;
GALLON, L ;
YUNKER, R ;
GLUECK, CJ .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1980, 33 (02) :251-259
[26]   PHYSICAL-PROPERTIES OF PURE SUCROSE OCTAESTERS [J].
JANDACEK, RJ ;
WEBB, MR .
CHEMISTRY AND PHYSICS OF LIPIDS, 1978, 22 (02) :163-176
[27]   THE EFFECT OF NONABSORBABLE LIPIDS ON THE INTESTINAL-ABSORPTION OF LIPOPHILES [J].
JANDACEK, RJ .
DRUG METABOLISM REVIEWS, 1982, 13 (04) :695-714
[28]  
JANDACEK RJ, 1977, Patent No. 4005195
[29]  
JOHNSTON RW, 1993, Patent No. 5194281
[30]  
JUST R, 1993, AM J GASTROENTEROL, V88, P1734