Turning off the Ras switch with the flick of a finger

被引：15

作者：

Noel, JP

机构：

[1] The Salk Institute for Biological Studies,the Structural Biology Laboratory

来源：

NATURE STRUCTURAL BIOLOGY | 1997年 / 4卷 / 09期

关键词：

D O I：

10.1038/nsb0997-677

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Structural and biochemical analysis of the interaction of Ras with GTPase activating proteins (GAPs) explains the stereochemical basis for the GAP mediated GTPase stimulation.

引用

页码：677 / 680

页数：4

共 15 条

[11] IS THERE A RATE-LIMITING STEP BEFORE GTP CLEAVAGE BY H-RAS P21 [J].

RENSLAND, H ;

LAUTWEIN, A ;

WITTINGHOFER, A ;

GOODY, RS .

BIOCHEMISTRY, 1991, 30 (46) :11181-11185

[12] The Ras-RasGAP complex: Structural basis for GTPase activation and its loss in oncogenic Ras mutants [J].

Scheffzek, K ;

Ahmadian, MR ;

Kabsch, W ;

Wiesmuller, L ;

Lautwein, A ;

Schmitz, F ;

Wittinghofer, A .

SCIENCE, 1997, 277 (5324) :333-338

[13] Crystal structure of the GTPase-activating domain of human p120GAP and implications for the interaction with Ras [J].

Scheffzek, K ;

Lautwein, A ;

Kabsch, W ;

Ahmadian, MR ;

Wittinghofer, A .

NATURE, 1996, 384 (6609) :591-596

[14] GTPASE MECHANISM OF GPROTEINS FROM THE 1.7-ANGSTROM CRYSTAL-STRUCTURE OF TRANSDUCIN ALPHA-CENTER-DOT-GDP-CENTER-DOT-ALF4(-) [J].

SONDEK, J ;

LAMBRIGHT, DG ;

NOEL, JP ;

HAMM, HE ;

SIGLER, PB .

NATURE, 1994, 372 (6503) :276-279

[15] Structure of RGS4 bound to AlF4--activated G(i alpha 1): Stabilization of the transition state for GTP hydrolysis [J].

Tesmer, JJG ;

Berman, DM ;

Gilman, AG ;

Sprang, SR .

CELL, 1997, 89 (02) :251-261

← 1 2 →