Dynamic changes in serum angiopoietin-1, angiopoietin-2, and angiopoietin-2/angiopoietin-1 ratio in acute myocardial infarction patients treated with primary percutaneous coronary intervention

被引：21

作者：

Chen, Shaomin ^{[1
]}

Guo, Lijun ^{[1
]}

Cui, Ming ^{[1
]}

Sun, Lijie ^{[1
]}

Mi, Lin ^{[1
]}

机构：

[1] Peking Univ Third Hosp, Key Lab Cardiovasc Mol Biol & Regulatory Peptides, Minist Hlth, Key Lab Mol Cardiovasc Sci,Minist Educ,Dept Cardi, Beijing, Peoples R China

来源：

BIOMARKERS | 2012年 / 17卷 / 05期

关键词：

Acute myocardial infarction; angiopoietin; cardiovascular disease; REPERFUSION INJURY; ENDOTHELIAL-CELLS; RECEPTOR TIE-2; GROWTH; ANGIOGENESIS; RISK; ISCHEMIA;

D O I：

10.3109/1354750X.2012.684152

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Context: Angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) play divergent roles in myocardial ischemia and reperfusion injury. Objective: To investigate serum Ang-1 and Ang-2 levels in ST-segment elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (PCI). Methods: Serum Ang-1 and Ang-2 were measured in 85 STEMI patients in the first week after PCI. Results: Ang-1, Ang-2 and Ang-2/Ang-1 ratio (Ang-2/1) were all increased at admission, and had dynamic changes after PCI. Ang-2 and Ang-2/1 at admission and 2 h after PCI were positively correlated with peak cardiac troponin T levels. Conclusion: The extent of myocardial damage may be linked to circulating Ang-2 and Ang-2/1.

引用

收藏

页码：441 / 446

页数：6

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