Peptidomimetics and Peptide Backbone Modifications

被引：98

作者：

Ahn, Jung-Mo ^{[1
]}

Boyle, Nicholas A. ^{[1
]}

MacDonald, Mary T. ^{[1
]}

Janda, Kim D. ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2002年 / 2卷 / 05期

关键词：

D O I：

10.2174/1389557023405828

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The replacement of the amide bond in a peptide backbone is a widely used form of peptide mimicry. Several of the most common amide bond surrogates, including peptidomimetic work done in this laboratory, and their biological applications are presented in this review.

引用

页码：463 / 473

页数：11

共 112 条

[81] 2-B
[82] beta-peptides: a surprise at every turn
Seebach, D
Matthews, JL
[J]. CHEMICAL COMMUNICATIONS, 1997, (21) : 2015 - 2022
[83] THIOCYCLOSPORINS - PREPARATION, SOLUTION AND CRYSTAL-STRUCTURE, AND IMMUNOSUPPRESSIVE ACTIVITY
SEEBACH, D
KO, SY
KESSLER, H
KOCK, M
REGGELIN, M
SCHMIEDER, P
WALKINSHAW, MD
BOLSTERLI, JJ
BEVEC, D
[J]. HELVETICA CHIMICA ACTA, 1991, 74 (08) : 1953 - 1990
[84] beta-peptides: Synthesis by Arndt-Eistert homologation with concomitant peptide coupling. Structure determination by NMR and CD spectroscopy and by X-ray crystallography. Helical secondary structure of a beta-hexapeptide in solution and its stability towards pepsin
Seebach, D
Overhand, M
Kuhnle, FNM
Martinoni, B
Oberer, L
Hommel, U
Widmer, H
[J]. HELVETICA CHIMICA ACTA, 1996, 79 (04) : 913 - 941
[85] β2- and β3-peptides with proteinaceous side chains:: Synthesis and solution structures of constitutional isomers, a novel helical secondary structure and the influence of solvation and hydrophobic interactions on folding
Seebach, D
Abele, S
Gademann, K
Guichard, G
Hintermann, T
Jaun, B
Matthews, JL
Schreiber, JV
[J]. HELVETICA CHIMICA ACTA, 1998, 81 (05) : 932 - 982
[86] Synthesis and biological activity of P-2-P-4 azapeptidomimetic P-1-argininal and P-1-ketoargininamide derivatives: A novel class of serine protease inhibitors
Semple, JE
Rowley, DC
Brunck, TK
Ripka, WC
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1997, 7 (03) : 315 - 320
[87] Shoisake K., 1993, BIOORG MED CHEM LETT, V5, P855
[88] Shue Y K, 1993, Bioorg Med Chem, V1, P161, DOI 10.1016/S0968-0896(00)82117-3
[89] AMIDE BOND SURROGATES - A GENERAL SYNTHETIC ROUTE TO TRANS CARBON-CARBON DOUBLE-BOND ISOSTERES
SHUE, YK
CARRERA, GM
NADZAN, AM
[J]. TETRAHEDRON LETTERS, 1987, 28 (28) : 3225 - 3228
[90] AMIDE BOND SURROGATES - A NOVEL ALTERNATE SYNTHESIS OF THE LEU-ASP TRANS CARBON-CARBON DOUBLE-BOND ISOSTERE OF CCK4
SHUE, YK
TUFANO, MD
NADZAN, AM
[J]. TETRAHEDRON LETTERS, 1988, 29 (33) : 4041 - 4044

← 3 4 5 6 7 8 9 10 11 12 →