Polarity proteins in migration and invasion

被引：230

作者：

Etienne-Manneville, S. ^{[1
,2
]}

机构：

[1] Inst Pasteur, Cell Polar & Migrat Grp, F-74724 Paris 15, France

[2] CNRS, URA 2582, F-74724 Paris 15, France

来源：

ONCOGENE | 2008年 / 27卷 / 55期

关键词：

Par proteins; epithelial mesenchymal transition (EMT); Rho GTPases; Wnt; Scribble;

D O I：

10.1038/onc.2008.347

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cancer is the result of the deregulation of cell proliferation and cell migration. In advanced tumors, cells invade the surrounding tissue and eventually form metastases. This is particularly evident in carcinomas in which epithelial cells have undergone epithelial-mesenchymal transition. Increased cell migration often correlates with a weakening of intercellular interactions. Junctions between neighboring epithelial cells are required to establish and maintain baso-apical polarity, suggesting that not only loss of cell-cell adhesion but also alteration of cell polarity is involved during invasion. Accordingly, perturbation of cell polarity is an important hallmark of advanced invasive tumors. Cell polarity is also essential for cell migration. Indeed, a front-rear polarity axis has first to be generated to allow a cell to migrate. Because cells migrate during invasion, cell polarity is not completely lost. Instead, polarity is modified. From a nonmigrating baso-apically polarized epithelial phenotype, cells acquire a polarized migrating mesenchymal phenotype. The aim of this review is to highlight the molecular relationship between the control of cell polarity and the regulation of cell motility during oncogenesis.

引用

页码：6970 / 6980

页数：11

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