Neurotensin and dopamine D2 activation oppositely regulate the same K+ conductance in rat midbrain dopaminergic neurons

被引：30

作者：

Farkas, RH

Chien, PY

Nakajima, S

Nakajima, Y

机构：

[1] UNIV ILLINOIS,COLL MED,DEPT ANAT & CELL BIOL,CHICAGO,IL 60612

[2] UNIV ILLINOIS,DEPT PHARMACOL,COLL MED,CHICAGO,IL 60612

来源：

NEUROSCIENCE LETTERS | 1997年 / 231卷 / 01期

关键词：

neurotensin; dopamine; interaction; ventral tegmental area; electrophysiology; whole-cell patch clamp; potassium current; inward rectifier;

D O I：

10.1016/S0304-3940(97)00530-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Midbrain dopaminergic neurons are excited by neurotensin (NT) and inhibited by dopamine. Interactions between these neurotransmitters have been reported, but no interaction has yet been identified at the level of ionic and signal transduction mechanisms, Using the whole-cell clamp technique, we examined the interaction of NT and quinpirole (QUIN) (a dopamine D2 agonist) on midbrain ventral tegmental area neurons cultured from the rat. We found that NT could inhibit the K+ conductance induced by QUIN. By interrupting normal signal transduction with the non-hydrolyzable GTP analogue GTP gamma S, we found that this interaction occurred downstream of the membrane neurotransmitter receptors. Similar interactions were observed between QUIN and tachykinin or metabotropic glutamate agonists. (C) 1997 Elsevier Science Ireland Ltd.

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页码：21 / 24

页数：4

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