pfmdr1 mutations in imported African Plasmodium falciparum isolates

被引：6

作者：

Dippmann, Anja K. ^{[1
]}

Bienzle, Ulrich ^{[1
]}

Harms, Gundel ^{[1
]}

Mockenhaupt, Frank P. ^{[1
]}

机构：

[1] Charite Univ Med Berlin, Inst Trop Med & Int Hlth, D-14050 Berlin, Germany

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 2008年 / 102卷 / 11期

关键词：

Malaria; pfmdr1; Drug resistance; Amodiaquine; Artesunate; Lumefantrine; Africa;

D O I：

10.1016/j.trstmh.2008.04.001

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 [公共卫生与预防医学]; 120402 [社会医学与卫生事业管理];

摘要：

Amodiaquine/artesunate and artemether/lumefantrine are currently implemented as antimalarial drugs in Africa. In this study, we assessed Plasmodium falciparum pfmdr1 alleles suggesting reduced sensitivity to amodiaquine/artesunate (86Y-184Y-1246Y) and artemether/lumefantrine (184F and 86N-184F-1246D) in 111 African isolates imported to Germany between 1997 and 2005. pfmdr1 86Y-184Y-1246Y occurred less frequently in West African isolates (2.5%) than in East African parasites (45.8%) (P<0.001) and less frequently in infections contracted in countries currently implementing amodiaquine/artesunate (5.7%) compared with countries with an artemether/lumefantrine policy (20.8%) (P = 0.03). pfmdr1 184F showed an opposite pattern. pfmdr1 alleles reveal significant differences between West and East Africa, supporting the current implementation of first-tine antimalarials. (C) 2008 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All. rights reserved.

引用

页码：1148 / 1150

页数：3

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