Determinants of p,p′-dichlorodiphenyldichloroethane (DDE) concentration in adipose tissue in women from five European cities

被引:26
作者
Sanz-Gallardo, MI
Guallar, E
Van't Veer, P
Longnecker, MP
Strain, JJ
Martin, BC
Kardinaal, AFM
Fernández-Crehuet, J
Thamm, M
Kohlmeier, L
Kok, FJ
Martín-Moreno, JM
机构
[1] Inst Salud Carlos III, Natl Sch Publ Hlth, Dept Epidemiol & Bioestadist, Madrid 28029, Spain
[2] Wageningen Univ Agr, Div Human Nutr & Epidemiol, Wageningen, Netherlands
[3] NIEHS, Epidemiol Branch, Res Triangle Pk, NC 27709 USA
[4] Univ Ulster, No Ireland Ctr Diet & Hlth, Coleraine BT52 1SA, Londonderry, North Ireland
[5] Univ Zurich, Inst Social & Prevent Med, CH-8006 Zurich, Switzerland
[6] TNO, Inst Toxicol & Nutr, NL-3700 AJ Zeist, Netherlands
[7] Univ Malaga, Dept Prevent Med, E-29071 Malaga, Spain
[8] Robert Koch Inst, Dept Hlth Risks & Prevent, D-1000 Berlin, Germany
[9] Univ N Carolina, Dept Epidemiol & Nutr, Chapel Hill, NC USA
来源
ARCHIVES OF ENVIRONMENTAL HEALTH | 1999年 / 54卷 / 04期
关键词
D O I
10.1080/00039899909602486
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
To identify the determinants of p,p'-dichlorodiphenyldichloroethane (p,p'-DDE) in adipose tissue in subjects who participated in a cross-sectional study, we analyzed fatty acids, antioxidants, and p,p'-DDE in aspirates of adipose tissue of 328 postmenopausal women from 5 European countries. The overall mean of p,p'-DDE concentration was 1.66 mu g/g of fatty acids (95% confidence interval = 1.46, 1.88). In a multiple-regression analysis, the main predictors of log(10)(p,p'-DDE) were center of recruitment (p <.0001), adipose arachidic acid (p =.001), and adipose retinol (p =.04). These factors explained 14.9% of the overall variability of log(10)(p,p'-DDE), In our subjects, adipose tissue p,p'-DDE concentrations were only weakly related with biomarkers reflecting intake of fish and other foods. This result is consistent with the notion that p,p'-DDE exists in different foods and, given the widespread contamination of the food chain, is relatively evenly distributed among foods.
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页码:277 / 283
页数:7
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