No evidence for a role of xenotropic murine leukaemia virus-related virus and BK virus in prostate cancer of German patients

被引：11

作者：

Akguel, Baki ^{[1
]}

Pfister, David ^{[2
]}

Knuechel, Ruth ^{[3
]}

Heidenreich, Axel ^{[2
]}

Wieland, Ulrike ^{[1
]}

Pfister, Herbert ^{[1
]}

机构：

[1] Univ Cologne, Inst Virol, Natl Reference Ctr Papillomaviruses & Polyomaviru, D-50935 Cologne, Germany

[2] Rhein Westfal TH Aachen, Dept Urol Oncol Urol Pediat Urol & Renal Transpla, D-52074 Aachen, Germany

[3] Rhein Westfal TH Aachen, Inst Pathol, D-52074 Aachen, Germany

来源：

MEDICAL MICROBIOLOGY AND IMMUNOLOGY | 2012年 / 201卷 / 02期

关键词：

Prostate cancer; Viral infection; BKPyV; XMRV; CHRONIC-FATIGUE-SYNDROME; XMRV; ASSOCIATION; PREVALENCE; INFECTION; SEQUENCES; DISEASE; TUMORS; DNA;

D O I：

10.1007/s00430-011-0215-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Prostate cancer is one of the most prevalent types of cancer in men. Controversial data exist concerning the role of BKPyV and the xenotropic murine leukaemia virus-related gammaretrovirus (XMRV) in prostate cancer development. We therefore assessed the association between prostate cancer and viral infections. We could detect BKPyV in only 1 out of 85 prostate cancer samples, whereas none of the tissue samples showed evidence for XMRV positivity. Lack of detection of BKPyV and XMRV in prostate cancer tissues suggests that these viruses do not play a role in the pathogenesis of this type of cancer.

引用

页码：245 / 248

页数：4

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