The metaphase to anaphase transition - A case of productive destruction

被引:16
作者
Farr, KA [1 ]
Cohen-Fix, O [1 ]
机构
[1] NIDDK, Mol & Cellular Biol Lab, NIH, Bethesda, MD 20892 USA
来源
EUROPEAN JOURNAL OF BIOCHEMISTRY | 1999年 / 263卷 / 01期
关键词
cell cycle; mitosis; anaphase promoting complex; cyclosome; mitotic checkpoint; protein degradation;
D O I
10.1046/j.1432-1327.1999.00510.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The metaphase to anaphase transition is a point of no return; the duplicated sister chromatids segregate to the future daughter cells, and any mistake in this process may be deleterious to both progeny. At the heart of this process lies the anaphase inhibitor, which must be degraded in order for this transition to take place. The degradation of the anaphase inhibitor occurs via the ubiquitin-degradation pathway, and it involves the activity of the cyclosome/anaphase promoting complex (APC). The fidelity of the metaphase to anaphase transition is ensured by several different regulatory mechanisms that modulate the activity of the cyclosome/APC. Great advancements have been mode in this field in the past few years, but many questions still remain to be answered.
引用
收藏
页码:14 / 19
页数:6
相关论文
共 52 条
[1]   Regulation of B-type cyclin proteolysis by Cdc28-associated kinases in budding yeast [J].
Amon, A .
EMBO JOURNAL, 1997, 16 (10) :2693-2702
[2]   Mutations of mitotic checkpoint genes in human cancers [J].
Cahill, DP ;
Lengauer, C ;
Yu, J ;
Riggins, GJ ;
Willson, JKV ;
Markowitz, SD ;
Kinzler, KW ;
Vogelstein, B .
NATURE, 1998, 392 (6673) :300-303
[3]   The Polo-related kinase Cdc5 activates and is destroyed by the mitotic cyclin destruction machinery in S. cerevisiae [J].
Charles, JF ;
Jespersen, SL ;
Tinker-Kulberg, RL ;
Hwang, L ;
Szidon, A ;
Morgan, DO .
CURRENT BIOLOGY, 1998, 8 (09) :497-507
[4]   Spindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochores [J].
Chen, RH ;
Shevchenko, A ;
Mann, M ;
Murray, AW .
JOURNAL OF CELL BIOLOGY, 1998, 143 (02) :283-295
[5]   An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast [J].
Ciosk, R ;
Zachariae, W ;
Michaelis, C ;
Shevchenko, A ;
Mann, M ;
Nasmyth, K .
CELL, 1998, 93 (06) :1067-1076
[6]   Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p [J].
CohenFix, O ;
Peters, JM ;
Kirschner, MW ;
Koshland, D .
GENES & DEVELOPMENT, 1996, 10 (24) :3081-3093
[7]   The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation [J].
Fang, GW ;
Yu, HT ;
Kirschner, MW .
GENES & DEVELOPMENT, 1998, 12 (12) :1871-1883
[8]   Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1 [J].
Fang, GW ;
Yu, HT ;
Kirschner, MW .
MOLECULAR CELL, 1998, 2 (02) :163-171
[9]   Bub1p kinase activates the Saccharomyces cerevisiae spindle assembly checkpoint [J].
Farr, KA ;
Hoyt, MA .
MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (05) :2738-2747
[10]   Fission yeast cut1 and cut2 are essential for sister chromatid separation, concentrate along the metaphase spindle and form large complexes [J].
Funabiki, H ;
Kumada, K ;
Yanagida, M .
EMBO JOURNAL, 1996, 15 (23) :6617-6628