The Human Cell Atlas

被引：1478

作者：

Regev, Aviv ^{[1
,2
,3
]}

Teichmann, Sarah A. ^{[4
,5
,6
]}

Lander, Eric S. ^{[1
,2
,7
]}

Amt, Ido ^{[8
]}

Benoist, Christophe ^{[9
]}

Birney, Ewen ^{[5
]}

Bodenmiller, Bernd ^{[10
]}

Campbell, Peter ^{[4
,11
]}

Carninci, Piero ^{[12
]}

Clatworthy, Menna ^{[13
]}

Clevers, Hans ^{[14
,15
]}

Deplancke, Bart ^{[16
]}

Dunham, Ian ^{[5
]}

Eberwine, James ^{[17
]}

Elis, Roland ^{[18
,19
]}

Enard, Wolfgang ^{[20
]}

Farmer, Andrew ^{[21
]}

Fugger, Lars ^{[22
,23
]}

Gottgens, Berthold ^{[24
,25
]}

Hacohen, Nir ^{[1
,26
]}

Haniffa, Muzlifah ^{[27
]}

Hemberg, Martin ^{[4
]}

Kim, Seung ^{[28
,29
]}

Klenerman, Paul ^{[30
,31
,32
]}

Kriegstein, Arnold ^{[33
]}

Lein, E. D. ^{[34
]}

Linnarsson, Sten ^{[35
]}

Lundberg, Emma ^{[36
]}

Lundeberg, Jaokim

Majumder, Partha ^{[37
]}

Marioni, John C. ^{[4
,5
,38
]}

Merad, Miriam ^{[39
]}

Mhlanga, Musa ^{[40
]}

Nawijin, Martijn ^{[41
]}

Netea, Mihai ^{[42
,43
]}

Nolan, Garry ^{[44
]}

Pe'er, Dana ^{[45
]}

Phillipakis, Anthony ^{[1
]}

Ponting, Chris P. ^{[46
]}

Quake, Stephen ^{[47
,48
,49
]}

Reik, Wolf ^{[4
,50
,51
]}

Rozenblatt-Rosen, Orit ^{[1
]}

Sanes, Joshua ^{[52
,53
]}

Satija, Rahul ^{[54
,55
]}

Schumacher, Ton N. ^{[56
]}

Shalek, Alex ^{[1
,57
,58
,59
]}

Shapiro, Ehud ^{[60
,61
]}

Sharma, Padmanee ^{[62
]}

Shin, Jay W. ^{[63
]}

Stegle, Oliver ^{[5
]}

机构：

[1] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA

[2] MIT, Dept Biol, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[3] Howard Hughes Med Inst, Chevy Chase, MD 20815 USA

[4] Wellcome Trust Sanger Inst, Wellcome Genome Campus, Hinxton, England

[5] EMBL European Bioinformat Inst, Wellcome Genome Campus, Hinxton, England

[6] Univ Cambridge, Dept Phys, Cavendish Lab, Cambridge, England

[7] Harvard Med Sch, Dept Syst Biol, Boston, MA 02115 USA

[8] Weizmann Inst Sci, Dept Immunol, Rehovot, Israel

[9] Harvard Med Sch, Dept Microbiol & Immunobiol, Div Immunol, Boston, MA USA

[10] Univ Zurich, Inst Mol Life Sci, Zurich, Switzerland

[11] Univ Cambridge, Dept Haematol, Cambridge, England

[12] RIKEN Ctr Life Sci Technol, Div Genom Technol, Yokohama, Kanagawa, Japan

[13] Univ Cambridge, MRC Lab Mol Biol, Dept Med, Mol Immun Unit, Cambridge, England

[14] Princess Maxima Ctr Pediat Oncol, Hubrecht Inst, Utrecht, Netherlands

[15] Univ Med Ctr Utrecht, Utrecht, Netherlands

[16] Swiss Fed Inst Technol EPFL, Sch Life Sci, Inst Bioengn, Lausanne, Switzerland

[17] Univ Penn, Perelman Sch Med, Dept Syst Pharmacol & Translat Therapeut, Philadelphia, PA 19104 USA

[18] German Canc Res Ctr, Div Theoret Bioinformat B080, Heidelberg, Germany

[19] Heidelberg Univ, Inst Pharm & Mol Biotechnol IPMB & BioQuant, Dept Bioinformat & Funct Genom, Heidelberg, Germany

[20] Ludwig Maximilian Univ Munich, Dept Biol 2, Martinsried, Germany

[21] Takara Bio United States Inc, Mountain View, CA USA

[22] Univ Oxford, Nuffield Dept Clin Neurosci, Oxford Ctr Neuroinflammat, Oxford, England

[23] Univ Oxford, MRC Human Immunol Unit, Weatherall Inst Mol Med, John Radcliffe Hosp, Oxford, England

[24] Univ Cambridge, Dept Haematol, Cambridge, England

[25] Univ Cambridge, Wellcome Trust MRC Cambridge Stem Cell Inst, Cambridge, England

[26] Massachusetts Gen Hosp, Canc Ctr, Boston, MA USA

[27] Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne, Tyne & Wear, England

[28] Stanford Univ, Sch Med, Dept Dev Biol, Stanford, CA USA

[29] Stanford Univ, Sch Med, Dept Med, Stanford, CA USA

[30] Univ Oxford, Nuffield Dept Clin Med, Peter Medawar Bldg Pathogen Res, Oxford, England

[31] Univ Oxford, Nuffield Dept Clin Med, Translat Gastroenterol Unit, Oxford, England

[32] John Radcliffe Hosp, Oxford NIHR Biomed Res Ctr, Oxford, England

[33] Univ Calif San Francisco, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell, San Francisco, CA 94143 USA

[34] Allen Inst Brain Sci, Seattle, WA USA

[35] Karolinska Inst, Dept Med Biochem & Biophys, Lab Mol Neurobiol, Stockholm, Sweden

[36] KTH Royal Inst Technol, Dept Gene Technol, Sci Life Lab, Stockholm, Sweden

[37] Natl Inst Biomed Genom, Kalyani, W Bengal, India

[38] Univ Cambridge, Canc Res UK Cambridge Inst, Cambridge, England

[39] Icahn Sch Med Mt Sinai, Precis Immunol Inst, New York, NY 10029 USA

[40] Univ Cape Town, Inst Infect Dis & Mol Med IDM, Dept Integrat Biomed Sci, Fac Hlth Sci,Div Chem Syst & Synthetic Biol, Cape Town, South Africa

[41] Univ Groningen, Univ Med Ctr Groningen, GRIAC Res Inst, Dept Pathol & Med Biol, Groningen, Netherlands

[42] Radboud Univ Nijmegen, Med Ctr, Dept Internal Med, Nijmegen, Netherlands

[43] Radboud Univ Nijmegen, Med Ctr, Radboud Ctr Infect Dis, Nijmegen, Netherlands

[44] Stanford Univ, Dept Microbiol & Immunol, Stanford, CA 94305 USA

[45] Sloan Kettering Inst, Computat & Syst Biol Program, New York, NY USA

[46] Univ Edinburgh, MRC Inst Genet & Mol Med, MRC Human Genet Unit, Edinburgh, Midlothian, Scotland

[47] Stanford Univ, Dept Appl Phys, Stanford, CA 94305 USA

[48] Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA

[49] Chan Zuckerberg Biohub, San Francisco, CA USA

[50] Babraham Inst, Epigenet Programme, Cambridge, England

来源：

ELIFE | 2017年 / 6卷

基金：

英国生物技术与生命科学研究理事会;

关键词：

RNA-SEQ; GENE-EXPRESSION; MESSENGER-RNA; CHROMATIN ACCESSIBILITY; HEMATOPOIETIC STEM; TRANSCRIPTIONAL HETEROGENEITY; LINEAGE ANALYSIS; ANALYSIS REVEALS; DIFFUSION MAPS; FATE DECISIONS;

D O I：

10.7554/eLife.27041

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The recent advent of methods for high-throughput single-cell molecular profiling has catalyzed a growing sense in the scientific community that the time is ripe to complete the 150-year-old effort to identify all cell types in the human body. The Human Cell Atlas Project is an international collaborative effort that aims to define all human cell types in terms of distinctive molecular profiles (such as gene expression profiles) and to connect this information with classical cellular descriptions (such as location and morphology). An open comprehensive reference map of the molecular state of cells in healthy human tissues would propel the systematic study of physiological states, developmental trajectories, regulatory circuitry and interactions of cells, and also provide a framework for understanding cellular dysregulation in human disease. Here we describe the idea, its potential utility, early proofs-of-concept, and some design considerations for the Human Cell Atlas, including a commitment to open data, code, and community.

引用

页数：30

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