Drug leads from the Kallawaya herbalists of Bolivia .1. Background, rationale, protocol and anti-HIV activity

被引：32

作者：

AbdelMalek, S

Bastien, JW

Mahler, WF

Jia, Q

Reinecke, MG

Robinson, WE

Shu, YH

ZallesAsin, J

机构：

[1] TEXAS CHRISTIAN UNIV,DEPT CHEM,FT WORTH,TX 76129

[2] UNIV TEXAS,DEPT ANTHROPOL & SOCIOL,ARLINGTON,TX 76019

[3] BOT RES INST TEXAS,FT WORTH,TX 76102

[4] UNIV CALIF IRVINE,DEPT PATHOL,IRVINE,CA 92717

[5] UNIV CALIF IRVINE,DEPT MICROBIOL,IRVINE,CA 92717

[6] UNIV CALIF IRVINE,DEPT MOLEC GENET,IRVINE,CA 92717

[7] SERV INTEGRADO SALUD,LA PAZ,BOLIVIA

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 1996年 / 50卷 / 03期

关键词：

Bolivia; HIV; Kallawaya; medicinal plants;

D O I：

10.1016/0378-8741(96)01380-3

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Aqueous, organic and alcoholic extracts of over 100 samples of 60 species of Kallawaya medicinal herbs representing 30 plant families were assayed to compare their toxicity and ability to protect MT-2 T-lymphoblastoid cells from the cytopathic effect of human immunodeficiency virus (HIV). The results are reported as a therapeutic index (TI) which was > 25 for eighteen species, including seven > 50 and one > 100. The anti-HIV activity resided primarily in the aqueous rather than in the organic extracts and was concentrated in plants used in ethnomedicine to treat lung and liver diseases.

引用

页码：157 / 166

页数：10

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