In vitro activity of fluvastatin, a cholesterol-lowering agent, and synergy with fluconazole and itraconazole against Candida species and Cryptococcus neoformans

Fluvastatin, a cholesterol-lowering drug, exhibited minimal activity (MICs of 64 to >128 mu g/ml) against Candida species and Cryptococcus neoformans. When fluvastatin was combined with fluconazole or itraconazole, both synergistic and additive effects were noted (fractional inhibitory concentration indices of less than or equal to 0.156 to 0.625; fractional lethal concentration indices of less than or equal to 0.156 to 0.75). This combined fungicidal activity was confirmed by time-versus-killing studies.