DEMONSTRATION OF SYNERGY WITH FLUCONAZOLE AND EITHER IBUPROFEN, SODIUM-SALICYLATE, OR PROPYLPARABEN AGAINST CANDIDA-ALBICANS IN-VITRO

The combination of fluconazole with either ibuprofen, sodium salicylate, or propylparaben resulted in synergistic activity (fractional inhibitory index, <0.5) against Candida albicans NCYC 610 in a microdilution checkerboard assay. Synergism between miconazole and ibuprofen was also demonstrated, In three of four clinical isolates of C. albicans from AIDS patients, the combination of fluconazole and ibuprofen was synergistic, Preparation of the inoculum and the growth conditions used were those recommended by the National Committee for Clinical Laboratory Standards for susceptibility testing. A visual estimation of total inhibition of growth and determination of an 80% reduction in the optical density at 492 nm compared,vith those for the control were taken as endpoints for the calculation of synergy, and a good correlation between both estimates was demonstrated.