Cell migration and axon growth cone guidance in Caenorhabditis elegans

被引:16
作者
Branda, CS [1 ]
Stern, MJ [1 ]
机构
[1] Yale Univ, Sch Med, Dept Genet, New Haven, CT 06520 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1016/S0959-437X(99)80073-2
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
In the past year, several new components involved in cell migration and axon guidance have been identified by genetic analysis in Caenorhabditis elegans, taking us a step closer to being able to trace the pathways which mediate these processes. The completion of the C. elegans genome sequencing project has provided us with the knowledge of the full spectrum of genes that might be involved in cell migration and axon guidance, and can facilitate the analysis of components that have been shown to be important for these processes in other systems.
引用
收藏
页码:479 / 484
页数:6
相关论文
共 45 条
[11]  
Forrester WC, 1997, DEVELOPMENT, V124, P1831
[12]  
Forrester WC, 1998, GENETICS, V148, P151
[13]   The VAB-1 Eph receptor tyrosine kinase functions in neural and epithelial morphogenesis in C-elegans [J].
George, SE ;
Simokat, K ;
Hardin, J ;
Chisholm, AD .
CELL, 1998, 92 (05) :633-643
[14]  
GUO C, 1995, THESIS J HOPKINS U
[15]   Rho GTPases and the actin cytoskeleton [J].
Hall, A .
SCIENCE, 1998, 279 (5350) :509-514
[16]   EXPRESSION OF THE UNC-5 GUIDANCE RECEPTOR IN THE TOUCH NEURONS OF C-ELEGANS STEERS THEIR AXONS DORSALLY [J].
HAMELIN, M ;
ZHOU, YW ;
SU, MW ;
SCOTT, IM ;
CULOTTI, JG .
NATURE, 1993, 364 (6435) :327-330
[17]  
Harris J, 1996, DEVELOPMENT, V122, P3117
[18]   Netrins evoke mixed reactions in motile cells [J].
Hedgecock, EM ;
Norris, CR .
TRENDS IN GENETICS, 1997, 13 (07) :251-253
[19]   THE UNC-5, UNC-6, AND UNC-40 GENES GUIDE CIRCUMFERENTIAL MIGRATIONS OF PIONEER AXONS AND MESODERMAL CELLS ON THE EPIDERMIS IN C-ELEGANS [J].
HEDGECOCK, EM ;
CULOTTI, JG ;
HALL, DH .
NEURON, 1990, 4 (01) :61-85
[20]  
Herman MA, 1999, DEVELOPMENT, V126, P1055