Immunity, inflammation and cancer: a leading role for adenosine

被引：602

作者：

Antonioli, Luca ^{[1
,2
,3
]}

Blandizzi, Corrado ^{[1
]}

Pacher, Pal ^{[4
]}

Hasko, Gyoergy ^{[2
,3
,5
]}

机构：

[1] Univ Pisa, Dept Clin & Expt Med, I-56126 Pisa, Italy

[2] Rutgers New Jersey Med Sch, Dept Surg, Newark, NJ 07103 USA

[3] Rutgers New Jersey Med Sch, Ctr Immun & Inflammat, Newark, NJ 07103 USA

[4] NIAAA, Sect Oxidat Stress Tissue Injury, Labs Physiol Studies, NIH, Bethesda, MD 20892 USA

[5] Univ Debrecen, Med & Hlth Sci Ctr, Dept Med Chem, H-4032 Debrecen, Hungary

来源：

NATURE REVIEWS CANCER | 2013年 / 13卷 / 12期

基金：

美国国家卫生研究院; 匈牙利科学研究基金会;

关键词：

ENDOTHELIAL GROWTH-FACTOR; ACTIVATED PROTEIN-KINASE; REGULATORY T-CELLS; TUMOR-ASSOCIATED MACROPHAGES; NUCLEOSIDE TRANSPORTER FAMILY; RECEPTOR MEDIATES APOPTOSIS; SYNERGISTIC UP-REGULATION; AUGMENTS IL-10 PRODUCTION; REDUCING ERK1/2 ACTIVITY; COLON-CARCINOMA GROWTH;

D O I：

10.1038/nrc3613

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer is a complex disease that is dictated by both cancer cell-intrinsic and cell-extrinsic processes. Adenosine is an ancient extracellular signalling molecule that can regulate almost all aspects of tissue function. As such, several studies have recently highlighted a crucial role for adenosine signalling in regulating the various aspects of cell-intrinsic and cell-extrinsic processes of cancer development. This Review critically discusses the role of adenosine and its receptors in regulating the complex interplay among immune, inflammatory, endothelial and cancer cells during the course of neoplastic disease.

引用

页码：842 / 857

页数：16

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