Concise synthesis of 22-hydroxyacuminatine, cytotoxic camptothecinoid from Camptotheca acuminata, by pyridone benzannulation

被引：30

作者：

Babjak, M ^{[1
]}

Kanazawa, A ^{[1
]}

Anderson, RJ ^{[1
]}

Greene, AE ^{[1
]}

机构：

[1] Univ Grenoble 1, LEDSS, F-38041 Grenoble, France

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2006年 / 4卷 / 03期

关键词：

D O I：

10.1039/b516154a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A short, efficient synthesis of 22-hydroxyacuminatine, starting from a readily accessible hydroxy pyridone, is presented; key steps include a Heck coupling with methyl pentadienoate, a flash vacuum pyrolytic cyclization, and a Friedlander condensation.

引用

收藏

页码：407 / 409

页数：3

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