Synthesis of enantiopure α′-amino α,β-epoxy ketones from α′-amino bromomethyl ketones

被引：22

作者：

Barluenga, J

Baragaña, B

Concellón, JM

Piñera-Nicolás, A

Díaz, MR

García-Granda, S

机构：

[1] Univ Oviedo, Inst Quim Organomet Enrique Moles, E-33071 Oviedo, Spain

[2] Univ Oviedo, Fac Quim, Dept Quim Fis & Analit, E-33071 Oviedo, Spain

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1999年 / 64卷 / 14期

关键词：

D O I：

10.1021/jo982435z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Preparation of enantiomerically pure alpha'-amino alpha,beta-epoxy ketones 2 in an efficient synthesis starting from alpha'-amino bromomethyl ketones 5 and the obtention of amino diepoxido 10a as synthetic application of 2 are described. We also report the generalization of the synthesis of 1-aminoalkyl halomethyl ketones to their bromo derivatives.

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页码：5048 / 5052

页数：5

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