Synthetic applications of 1-aminoalkyl chloromethyl ketones. Synthesis of enantiopure 3-azetidinols and aminoalkyl epoxides

被引：23

作者：

Barluenga, J

Baragana, B

Concellon, JM

机构：

[1] Inst. Univ. de Quim. Orgmet. E., Universidad de Oviedo, 33071 Oviedo, Julián Clavería s / n

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1997年 / 62卷 / 17期

关键词：

D O I：

10.1021/jo9700585

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Addition of several organocerium compounds to chiral 1-aminoalkyl chloromethyl ketones 1 affords, after deprotection, enantiomerically pure 3-azetidinols 5. The synthesis of enantiopure amino epoxides 8 is also described by successive treatment of chiral alpha-amino ketones 1 with organocerium compounds and methyllithium.

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页码：5974 / 5977

页数：4

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