Synthetic applications of 1-aminoalkyl chloromethyl ketones. Synthesis of enantiopure 3-azetidinols and aminoalkyl epoxides

被引:23
作者
Barluenga, J
Baragana, B
Concellon, JM
机构
[1] Inst. Univ. de Quim. Orgmet. E., Universidad de Oviedo, 33071 Oviedo, Julián Clavería s / n
关键词
D O I
10.1021/jo9700585
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Addition of several organocerium compounds to chiral 1-aminoalkyl chloromethyl ketones 1 affords, after deprotection, enantiomerically pure 3-azetidinols 5. The synthesis of enantiopure amino epoxides 8 is also described by successive treatment of chiral alpha-amino ketones 1 with organocerium compounds and methyllithium.
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收藏
页码:5974 / 5977
页数:4
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